naa a22 4500 510764363 CHVBK 20180411083151.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s12094-012-0900-5 doi (NATIONALLICENCE)springer-10.1007/s12094-012-0900-5 Co-expression of MMP-14 and MMP-19 predicts poor survival in human glioma [Elektronische Daten] [Liang Wang, Jun Yuan, Yanyang Tu, Xinggang Mao, Shiming He, Guoqiang Fu, Jianhai Zong, Yongsheng Zhang] Aim: Matrix metalloproteinase (MMP)-14 and MMP-19 have been demonstrated to play an important role in the development of human gliomas. However, their prognostic values are not clear. The aim of this study was to investigate whether co-expression of MMP-14 and MMP-19 has prognostic relevance in human gliomas. Methods: Immunohistochemistry and western blot were used to investigate the expression of MMP-14 and MMP-19 proteins in 128 patients with gliomas. Results: The expression levels of MMP-14 and MMP-19 proteins in glioma tissues were both significantly higher (both P<0.001) than those in non-neoplastic brain tissues according to the immunohistochemistry analysis, which was confirmed by the western blot analysis. Additionally, the overexpression of either MMP-14 or MMP-19 was significantly associated with the advanced WHO grade (both P=0.02), the low Karnofsky performance score (KPS) (P=0.008 and 0.01, respectively) and the poor overall survival (both P=0.01). Moreover, the Multivariate Cox proportional-hazards regression analysis revealed that the increased expressions of MMP-14 and MMP-19 were both independent prognostic factors for poor overall survival (both P=0.02). Furthermore, the co-expression of MMP-14 and MMP-19 was additively and more significantly (P=0.006) associated with adverse prognosis in patients with gliomas than respective expression of MMP-14 and MMP-19. Conclusions: These findings indicated for the first time that the co-expression of MMP-14 and MMP-19 is significantly correlated with prognosis in glioma patients, suggesting that the co-expression of these proteins may be used as both an early diagnostic and independent prognostic marker. Federación de Sociedades Españolas de Oncología (FESEO), 2012 Matrix metalloproteinase-14 nationallicence Matrix metalloproteinase-19 nationallicence Glioma nationallicence Immunohistochemistry nationallicence Western blot nationallicence Co-expression nationallicence Prognosis nationallicence Wang Liang Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, People's Republic of China aut Yuan Jun Administrative Department, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, People's Republic of China aut Tu Yanyang Department of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, People's Republic of China aut Mao Xinggang Department of Neurosurgery, 254th Hospital of PLA, 300142, Tianjin, People's Republic of China aut He Shiming Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, People's Republic of China aut Fu Guoqiang Department of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, People's Republic of China aut Zong Jianhai Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, People's Republic of China aut Zhang Yongsheng Administrative Department, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, People's Republic of China aut Clinical and Translational Oncology Springer Milan 15/2(2013-02-01), 139-145 1699-048X 15:2<139 2013 15 12094 https://doi.org/10.1007/s12094-012-0900-5 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0900-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Liang Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, People's Republic of China aut NATIONALLICENCE 700 1- Yuan Jun Administrative Department, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, People's Republic of China aut NATIONALLICENCE 700 1- Tu Yanyang Department of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, People's Republic of China aut NATIONALLICENCE 700 1- Mao Xinggang Department of Neurosurgery, 254th Hospital of PLA, 300142, Tianjin, People's Republic of China aut NATIONALLICENCE 700 1- He Shiming Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, People's Republic of China aut NATIONALLICENCE 700 1- Fu Guoqiang Department of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, People's Republic of China aut NATIONALLICENCE 700 1- Zong Jianhai Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, People's Republic of China aut NATIONALLICENCE 700 1- Zhang Yongsheng Administrative Department, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, People's Republic of China aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/2(2013-02-01), 139-145 1699-048X 15:2<139 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer