naa a22 4500 51076441X CHVBK 20180411083151.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s12094-012-0901-4 doi (NATIONALLICENCE)springer-10.1007/s12094-012-0901-4 Ultrasound-assisted endocavitary HDR-Ir192 brachytherapy for unresectable locally advanced uterine cervix carcinoma: retrospective analysis focusing the efficacy and tolerability [Elektronische Daten] [Georgios Koukourakis, Anthoula Miliadou, Ioannis Tsalafoutas, Elisavet Geli, Anastasia Sotiropoulou-Lontou] Purpose: To evaluate the impact of uterine cavity's ultrasound to final selected length of intracavitary tandem. The efficacy and tolerability of external beam radiation plus HDR-Ir192 brachytherapy in our cohort of patients were also estimated. Materials and methods: 48 women with locally advanced unresectable uterine cervix carcinoma were treated by HDR-Ir192 endocavitary brachytherapy between January 2007 and January 2009. The median age was 63 (range 38-74). The distribution according to Federation of Gynaecology and Obstetrics (FIGO) staging system was as follows: Stage IIB, 54.16%; IIIA, 10.4%; IIIB, 27.0%; and IVA, 8.3%. HDR intracavitary brachytherapy was given weekly, beginning at the last week of whole pelvis irradiation, with a dose of 7Gy to point A for three to four fractions. The median overall treatment time was 50days (range 42-73days). The median follow-up time was 2.7years (range 3months to 4.9years). Multivariate analysis was performed using the Cox regression proportional hazards model. Results: The complete remission rate after radiotherapy was 93.75% (45/48). The 5-year actuarial major complication rates (Grade 3 or above) were 6.3% overall (2.1% proctitis, 2.1% cystitis and 2.1% enteritis). Estimation of the length of uterine cavity by ultrasound helped decisively in the proper placement of the intrauterine tandem inserted. Conclusions: Prior knowledge of the length of uterine cavity can facilitate the decisions regarding the proper insertion length of the tandem. Results of cervical cancer treatment with external beam radiation and HDR intracavitary brachytherapy in our hospital are encouraging. Federación de Sociedades Españolas de Oncología (FESEO), 2012 HDR-Ir192 nationallicence Endocavitary brachytherapy nationallicence Uterine cervix carcinoma nationallicence Gynaecological cancer nationallicence External beam radiation therapy nationallicence Koukourakis Georgios Department of Second Radiation Therapy, Saint Savvas Anticancer Institute of Athens, Athens, Greece aut Miliadou Anthoula Department of Second Radiation Therapy, Saint Savvas Anticancer Institute of Athens, Athens, Greece aut Tsalafoutas Ioannis Department of Medical Physics, Saint Savvas Anticancer Institute of Athens, Athens, Greece aut Geli Elisavet Department of First Radiology, Saint Savvas Anticancer Institute of Athens, Athens, Greece aut Sotiropoulou-Lontou Anastasia Department of Second Radiation Therapy, Saint Savvas Anticancer Institute of Athens, Athens, Greece aut Clinical and Translational Oncology Springer Milan 15/2(2013-02-01), 154-159 1699-048X 15:2<154 2013 15 12094 https://doi.org/10.1007/s12094-012-0901-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-012-0901-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koukourakis Georgios Department of Second Radiation Therapy, Saint Savvas Anticancer Institute of Athens, Athens, Greece aut NATIONALLICENCE 700 1- Miliadou Anthoula Department of Second Radiation Therapy, Saint Savvas Anticancer Institute of Athens, Athens, Greece aut NATIONALLICENCE 700 1- Tsalafoutas Ioannis Department of Medical Physics, Saint Savvas Anticancer Institute of Athens, Athens, Greece aut NATIONALLICENCE 700 1- Geli Elisavet Department of First Radiology, Saint Savvas Anticancer Institute of Athens, Athens, Greece aut NATIONALLICENCE 700 1- Sotiropoulou-Lontou Anastasia Department of Second Radiation Therapy, Saint Savvas Anticancer Institute of Athens, Athens, Greece aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/2(2013-02-01), 154-159 1699-048X 15:2<154 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer