naa a22 4500 510764479 CHVBK 20180411083151.0 cr unu---uuuuu 180411e20131101xx s 000 0 eng 10.1007/s12094-013-1029-x doi (NATIONALLICENCE)springer-10.1007/s12094-013-1029-x Up-regulation of nuclear receptor coactivator amplified in breast cancer-1 in papillary thyroid carcinoma correlates with lymph node metastasis [Elektronische Daten] [M.-Y. Liu, H.-P. Guo, C.-Q. Hong, H.-W. Peng, X.-H. Yang, H. Zhang] Introduction: Nuclear receptor coactivator amplified in breast cancer-1 (AIB1), a new oncogenic coactivator, is commonly overexpressed and amplified in variety of human cancers. However, the expression of AIB1 in papillary thyroid carcinoma (PTC), the major histologic type of thyroid cancer, and its clinical significance are still unclear. Materials and methods: AIB1 expression in PTC was examined by immunohistochemistry using tissue microarrays comprised of 90 primary PTC, 46 matched lymph node, and 20 normal thyroid tissue specimens in this study. Results: In the normal thyroid specimens, AIB1 expression was either absent or at low levels. In contrast, AIB1 overexpression was detected in 50 of 83 (60.2%) primary PTC specimens. Up-regulated AIB1 was evident in 39 of 46 (73.5%) matched lymph nodes. Overexpression of AIB1 was observed more frequently in PTCs with lymph node metastasis [N1a/N1b, 39/46 (73.5%)] versus PTCs without lymph node metastasis [N0, 14/34 (41.2%)]. Furthermore, high-level AIB1 expression was only observed in the lymph node-positive specimens. Moreover, we found no correlation between AIB1 expression and ER expression in PTC tissues. Conclusions: Our findings suggest that overexpression of AIB1 may be a biomarker for tumorigenesis and progression of PTC and may play an important role in its acquisition of a metastatic phenotype. Federación de Sociedades Españolas de Oncología (FESEO), 2013 Papillary thyroid carcinoma nationallicence AIB1 nationallicence Oestrogen receptors nationallicence Immunohistochemistry nationallicence Tissue microarray nationallicence Liu M.-Y Department of Head and Neck Surgery, Cancer Hospital, Shantou University Medical College, 515000, Shantou, China aut Guo H.-P Department of Head and Neck Surgery, Cancer Hospital, Shantou University Medical College, 515000, Shantou, China aut Hong C.-Q Laboratory of Oncology, Cancer Hospital, Shantou University, 515000, Shantou, China aut Peng H.-W Department of Head and Neck Surgery, Cancer Hospital, Shantou University Medical College, 515000, Shantou, China aut Yang X.-H Department of Head and Neck Surgery, Cancer Hospital, Shantou University Medical College, 515000, Shantou, China aut Zhang H. Laboratory of Oncology, Cancer Hospital, Shantou University, 515000, Shantou, China aut Clinical and Translational Oncology Springer Milan 15/11(2013-11-01), 947-952 1699-048X 15:11<947 2013 15 12094 https://doi.org/10.1007/s12094-013-1029-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-013-1029-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu M.-Y Department of Head and Neck Surgery, Cancer Hospital, Shantou University Medical College, 515000, Shantou, China aut NATIONALLICENCE 700 1- Guo H.-P Department of Head and Neck Surgery, Cancer Hospital, Shantou University Medical College, 515000, Shantou, China aut NATIONALLICENCE 700 1- Hong C.-Q Laboratory of Oncology, Cancer Hospital, Shantou University, 515000, Shantou, China aut NATIONALLICENCE 700 1- Peng H.-W Department of Head and Neck Surgery, Cancer Hospital, Shantou University Medical College, 515000, Shantou, China aut NATIONALLICENCE 700 1- Yang X.-H Department of Head and Neck Surgery, Cancer Hospital, Shantou University Medical College, 515000, Shantou, China aut NATIONALLICENCE 700 1- Zhang H. Laboratory of Oncology, Cancer Hospital, Shantou University, 515000, Shantou, China aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/11(2013-11-01), 947-952 1699-048X 15:11<947 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer