naa a22 4500 510764509 CHVBK 20180411083151.0 cr unu---uuuuu 180411e20131101xx s 000 0 eng 10.1007/s12094-013-1028-y doi (NATIONALLICENCE)springer-10.1007/s12094-013-1028-y Prognostic significance of annexin II expression in non-small cell lung cancer [Elektronische Daten] [C.-H. Luo, Q.-Q. Liu, P.-F. Zhang, M.-Y. Li, Z.-C. Chen, Y.-F. Liu] Purpose: To discover common metastasis-related and prognostic markers in lung squamous carcinoma (LSC) and lung adenocarcinoma (AdC), two forms of non-small cell lung cancer (NSCLC). Methods: Quantitative proteomic analysis was performed between primary cancer tissues and matched lymph node metastatic tissues in LSC and AdC, respectively. Immunohistochemistry and statistic analysis were performed to investigate prognostic significance of metastasis-related protein annexin II expression in LSC and AdC. Results: Both in LSC and AdC, elevated expression of annexin II was identified in lymph node metastatic lung cancers compared to corresponding primary lung cancers. Furthermore, immunohistochemical analysis of a bulk of clinical specimens indicated that annexin II over-expression was more frequently observed in matched lymph node metastatic tissues than corresponding primary cancer tissues. Statistical analysis showed that annexin II over-expression was significantly associated with advanced clinical stage (P<0.05) and lymph node metastasis (P<0.05) and increased relapse rate (P<0.05) and decreased overall survival (P<0.05) in both two subtypes of NSCLC. Cox regression analysis indicated that annexin II over-expression was an important prognostic factor in both LSC and AdC. Conclusion: Annexin II was identified as a common prognostic factor in both LSC and AdC. Federación de Sociedades Españolas de Oncología (FESEO), 2013 Annexin II nationallicence NSCLC nationallicence Proteomics nationallicence Metastasis nationallicence Prognostic factor nationallicence Luo C.-H The Department of Pathology, The Traditional Chinese Medical Hospital of Xiamen, Xiamen, Fujian, People's Republic of China aut Liu Q.-Q Department of Basic Medical Sciences, Medical College, Xiamen University, 168# Daxue Road, 361005, Xiamen, Fujian, People's Republic of China aut Zhang P.-F Key Laboratory of Cancer Proteomics of Ministry of Health and Hunan Engineering Laboratory for Structural Biology and Drug Design, Central South University, Changsha, Hunan, People's Republic of China aut Li M.-Y Key Laboratory of Cancer Proteomics of Ministry of Health and Hunan Engineering Laboratory for Structural Biology and Drug Design, Central South University, Changsha, Hunan, People's Republic of China aut Chen Z.-C Key Laboratory of Cancer Proteomics of Ministry of Health and Hunan Engineering Laboratory for Structural Biology and Drug Design, Central South University, Changsha, Hunan, People's Republic of China aut Liu Y.-F Department of Basic Medical Sciences, Medical College, Xiamen University, 168# Daxue Road, 361005, Xiamen, Fujian, People's Republic of China aut Clinical and Translational Oncology Springer Milan 15/11(2013-11-01), 938-946 1699-048X 15:11<938 2013 15 12094 https://doi.org/10.1007/s12094-013-1028-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-013-1028-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Luo C.-H The Department of Pathology, The Traditional Chinese Medical Hospital of Xiamen, Xiamen, Fujian, People's Republic of China aut NATIONALLICENCE 700 1- Liu Q.-Q Department of Basic Medical Sciences, Medical College, Xiamen University, 168# Daxue Road, 361005, Xiamen, Fujian, People's Republic of China aut NATIONALLICENCE 700 1- Zhang P.-F Key Laboratory of Cancer Proteomics of Ministry of Health and Hunan Engineering Laboratory for Structural Biology and Drug Design, Central South University, Changsha, Hunan, People's Republic of China aut NATIONALLICENCE 700 1- Li M.-Y Key Laboratory of Cancer Proteomics of Ministry of Health and Hunan Engineering Laboratory for Structural Biology and Drug Design, Central South University, Changsha, Hunan, People's Republic of China aut NATIONALLICENCE 700 1- Chen Z.-C Key Laboratory of Cancer Proteomics of Ministry of Health and Hunan Engineering Laboratory for Structural Biology and Drug Design, Central South University, Changsha, Hunan, People's Republic of China aut NATIONALLICENCE 700 1- Liu Y.-F Department of Basic Medical Sciences, Medical College, Xiamen University, 168# Daxue Road, 361005, Xiamen, Fujian, People's Republic of China aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/11(2013-11-01), 938-946 1699-048X 15:11<938 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer