naa a22 4500 510764517 CHVBK 20180411083151.0 cr unu---uuuuu 180411e20131101xx s 000 0 eng 10.1007/s12094-013-1025-1 doi (NATIONALLICENCE)springer-10.1007/s12094-013-1025-1 Definitive radiotherapy for T1 glottic squamous cell carcinoma: a 15-year Cruces University Hospital experience [Elektronische Daten] [J. Cacicedo, F. Casquero, O. del Hoyo, A. Gomez-Iturriaga, L. Martinez-Indart, J. Lopez, P. Bilbao] Purpose: To evaluate the treatment outcomes for T1 N0 glottic carcinoma after definitive radiotherapy. Methods: One hundred and seventeen patients treated with radical radiotherapy from 1990 to 2006 were retrospectively reviewed. The median follow-up duration for the entire group was 92months (range 4-227). A median dose of 70Gy (range 63-70Gy) was administered. We determined the rates of local control (LC), regional control, overall survival (OS) and cause-specific survival (CSS) at 5, 10 and 15years by Kaplan-Meier product-limit method. The Cox regression analysis was performed to identify significant prognostic factors for LC and survival. The incidence of secondary malignancies is also reported. Results: The 5-, 10- and 15-year LC rates for the whole group were 84, 80.2 and 80.2%, respectively. There were 20 local recurrences, of which 19 were salvaged with laryngectomy, giving an ultimate control rate of 90.6%. The 5-/10-/15-year OS and CSS rates were 81.2%/66.1%/48.3% and 90.6%/90.6%/90.6%, respectively. None of the parameters analyzed exhibited a statistically significant relationship with LC. The age ≥65years had a statistically significant effect on OS (but not in CSS), with a hazard ratio of 2.45 (95% confidence interval 1.29-4.66; p=0.006). During follow-up, 26 patients (22%) developed a secondary malignancy. Only two patients (1.7%) presented with severe toxicity (edema and mucositis). Conclusions: Radiotherapy alone offers a high likelihood of LC and an excellent CSS rate. In addition, the surgical approach for the salvage is a successful option. Federación de Sociedades Españolas de Oncología (FESEO), 2013 Glottic carcinoma nationallicence Radiotherapy nationallicence Local control nationallicence Outcome nationallicence Cacicedo J. Department of Radiation Oncology, Cruces University Hospital, c/Plaza de Cruces s/n, 48903, Barakaldo, Vizcaya, Spain aut Casquero F. Department of Radiation Oncology, Cruces University Hospital, c/Plaza de Cruces s/n, 48903, Barakaldo, Vizcaya, Spain aut del Hoyo O. Department of Radiation Oncology, Cruces University Hospital, c/Plaza de Cruces s/n, 48903, Barakaldo, Vizcaya, Spain aut Gomez-Iturriaga A. Department of Radiation Oncology, Cruces University Hospital, c/Plaza de Cruces s/n, 48903, Barakaldo, Vizcaya, Spain aut Martinez-Indart L. Department of Clinical Epidemiology, Cruces University Hospital, Barakaldo, Vizcaya, Spain aut Lopez J. Department of Radiation Oncology, Virgen del Rocio University Hospital, Seville, Spain aut Bilbao P. Department of Radiation Oncology, Cruces University Hospital, c/Plaza de Cruces s/n, 48903, Barakaldo, Vizcaya, Spain aut Clinical and Translational Oncology Springer Milan 15/11(2013-11-01), 925-931 1699-048X 15:11<925 2013 15 12094 https://doi.org/10.1007/s12094-013-1025-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-013-1025-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cacicedo J. Department of Radiation Oncology, Cruces University Hospital, c/Plaza de Cruces s/n, 48903, Barakaldo, Vizcaya, Spain aut NATIONALLICENCE 700 1- Casquero F. Department of Radiation Oncology, Cruces University Hospital, c/Plaza de Cruces s/n, 48903, Barakaldo, Vizcaya, Spain aut NATIONALLICENCE 700 1- del Hoyo O. Department of Radiation Oncology, Cruces University Hospital, c/Plaza de Cruces s/n, 48903, Barakaldo, Vizcaya, Spain aut NATIONALLICENCE 700 1- Gomez-Iturriaga A. Department of Radiation Oncology, Cruces University Hospital, c/Plaza de Cruces s/n, 48903, Barakaldo, Vizcaya, Spain aut NATIONALLICENCE 700 1- Martinez-Indart L. Department of Clinical Epidemiology, Cruces University Hospital, Barakaldo, Vizcaya, Spain aut NATIONALLICENCE 700 1- Lopez J. Department of Radiation Oncology, Virgen del Rocio University Hospital, Seville, Spain aut NATIONALLICENCE 700 1- Bilbao P. Department of Radiation Oncology, Cruces University Hospital, c/Plaza de Cruces s/n, 48903, Barakaldo, Vizcaya, Spain aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/11(2013-11-01), 925-931 1699-048X 15:11<925 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer