naa a22 4500 510764606 CHVBK 20180411083152.0 cr unu---uuuuu 180411e20131101xx s 000 0 eng 10.1007/s12094-013-1024-2 doi (NATIONALLICENCE)springer-10.1007/s12094-013-1024-2 Estimate of the accelerated proliferation by protein tyrosine phosphatase (PTEN) over expression in postoperative radiotherapy of head and neck squamous cell carcinoma [Elektronische Daten] [P. Pedicini, A. Fiorentino, G. Improta, A. Nappi, M. Salvatore, G. Storto] Purpose: To estimate the impact of PTEN expression in terms of effective doubling time (T d) and dose per fraction which compensates the accelerated proliferation during the radiotherapy (D prolif) when the overall treatment time (OTT) is reduced in accelerated radiotherapy of head and neck squamous cell carcinoma (HNSCC). Materials and methods: Data were carried out from a recent paper comparing the local control rate (LCR) for patients with HNSCC that underwent a conventional (p-CF) or accelerated radiotherapy (p-CAIR) and a pretreatment assessment of PTEN expression. The impact of PTEN over expression was assessed using the Clinical Efficacy Factor (C) and assuming a plausible range of intrinsic radiosensitivity (α). Statistical analysis was made by evaluating the LCR from Kaplan-Meier curves and log-rank test with significance of 0.05. Results: C indexes were 1.46 and 0.23 for the high- versus low-PTEN group, corresponding to a considerable reduction of doubling time of more than six times (6.6 versus 42.2days). The median estimate of D prolif was 0.51 versus 0.08Gy/day if referred to a median value in the adopted range of α. Conclusions: The PTEN expression has a significant implication on the clinical management of these patient groups. Our data support the hypothesis that the high-PTEN group would benefit from a hypo-fractionation with a reduction of the OTT to compensate for the increase in the proliferation rate, while the low-PTEN group could benefits from a hyper-fractionation which would result in a reduced toxicity for all the organs at risk. Federación de Sociedades Españolas de Oncología (FESEO), 2013 PTEN expression nationallicence Doubling time nationallicence Accelerated proliferation nationallicence Radiosensitivity nationallicence Pedicini P. Department of Radiation Oncology, I.R.C.C.S. C.R.O.B Regional Cancer Hospital, 1-Padre-Pio-Street, 85028, Rionero in Vulture, PZ, Italy aut Fiorentino A. Department of Radiation Oncology, I.R.C.C.S. C.R.O.B Regional Cancer Hospital, 1-Padre-Pio-Street, 85028, Rionero in Vulture, PZ, Italy aut Improta G. Department of Radiation Oncology, I.R.C.C.S. C.R.O.B Regional Cancer Hospital, 1-Padre-Pio-Street, 85028, Rionero in Vulture, PZ, Italy aut Nappi A. Department of Radiation Oncology, I.R.C.C.S. C.R.O.B Regional Cancer Hospital, 1-Padre-Pio-Street, 85028, Rionero in Vulture, PZ, Italy aut Salvatore M. I.R.C.C.S. SDN Foundation, Naples, Italy aut Storto G. Department of Radiation Oncology, I.R.C.C.S. C.R.O.B Regional Cancer Hospital, 1-Padre-Pio-Street, 85028, Rionero in Vulture, PZ, Italy aut Clinical and Translational Oncology Springer Milan 15/11(2013-11-01), 919-924 1699-048X 15:11<919 2013 15 12094 https://doi.org/10.1007/s12094-013-1024-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12094-013-1024-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pedicini P. Department of Radiation Oncology, I.R.C.C.S. C.R.O.B Regional Cancer Hospital, 1-Padre-Pio-Street, 85028, Rionero in Vulture, PZ, Italy aut NATIONALLICENCE 700 1- Fiorentino A. Department of Radiation Oncology, I.R.C.C.S. C.R.O.B Regional Cancer Hospital, 1-Padre-Pio-Street, 85028, Rionero in Vulture, PZ, Italy aut NATIONALLICENCE 700 1- Improta G. Department of Radiation Oncology, I.R.C.C.S. C.R.O.B Regional Cancer Hospital, 1-Padre-Pio-Street, 85028, Rionero in Vulture, PZ, Italy aut NATIONALLICENCE 700 1- Nappi A. Department of Radiation Oncology, I.R.C.C.S. C.R.O.B Regional Cancer Hospital, 1-Padre-Pio-Street, 85028, Rionero in Vulture, PZ, Italy aut NATIONALLICENCE 700 1- Salvatore M. I.R.C.C.S. SDN Foundation, Naples, Italy aut NATIONALLICENCE 700 1- Storto G. Department of Radiation Oncology, I.R.C.C.S. C.R.O.B Regional Cancer Hospital, 1-Padre-Pio-Street, 85028, Rionero in Vulture, PZ, Italy aut NATIONALLICENCE 773 0- Clinical and Translational Oncology Springer Milan 15/11(2013-11-01), 919-924 1699-048X 15:11<919 2013 15 12094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer