naa a22 4500 510769276 CHVBK 20180411083207.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s11818-012-0599-0 doi (NATIONALLICENCE)springer-10.1007/s11818-012-0599-0 Allebrandt K.V. Institute of Medical Psychology, Medical Faculty, Ludwig-Maximilians-University, Goethestr. 31, 80336, Munich, Germany aut Sleep duration and metabolic syndrome [Elektronische Daten] A gene-environment association [K.V. Allebrandt] Schlafdauer und metabolisches Syndrom Eine Gen-Umwelt-Beziehung Extremes in duration of sleep have been associated with adverse health, specifically with the symptomatology characteristic of the metabolic syndrome. Body homeostasis and circadian rhythm are thought to interact and to influence energy metabolism. Environmental cues, such as time of year and amplitude of seasonal changes (changes in photoperiod length) influence both sleep behavior and energy metabolism, supporting a link between these two systems. However, little is known about the molecular mechanism underlying the relationships of sleep and the metabolic syndrome symptoms, or the sleep-circadian phenotypes per se. In genetic association studies on sleep duration (candidate clock genes approach and genome-wide association studies), we identified genes that are functionally involved in the development of the metabolic syndrome symptomatology. Although the relationship between sleep duration and body mass index may partly be caused by environmental influences such as voluntary sleep restriction and circadian misalignment, the association of sleep duration with genes related to metabolism indicates that genetic factors are central to it. In this article, the latest evidence of a gene-environment influence on the relationship of sleep duration with the metabolic syndrome symptomatology is discussed. Greater understanding of a common genetic pathway linking sleep duration to metabolic dysfunction, and the role of environment in the mediation of this relationship, will lead to the development of new guidelines for treatment of obesity, which is a major health issues in our society. Springer-Verlag Berlin Heidelberg, 2013 Sleep duration nationallicence Body mass index nationallicence Metabolic syndrome nationallicence Clock genes nationallicence Seasonality nationallicence Schlafdauer nationallicence Body-Mass-Index nationallicence Metabolisches Syndrom nationallicence Uhrengene nationallicence Saisonalität nationallicence BMAL1 : brain and muscle aryl hydrocarbon receptor nuclear translocator (ARNT)-like nationallicence CLOCK : circadian locomotor output cycles kaput nationallicence CRY : cryptochromes are a class of blue light-sensitive flavoproteins found in plants and animals nationallicence encoded by the genes CRY1 and CRY2 nationallicence DBP : D site of albumin promoter (albumin D-box) binding protein nationallicence DEC2 : BHLHB3 nationallicence class E basic helix-loop-helix protein 41 nationallicence Hyperkinetic : encodes a beta subunit of Shaker potassium channels in Drosophila nationallicence KCNAB1 : voltage-gated potassium channel subunit beta-1 nationallicence KIR : inwardly rectifying potassium channels nationallicence NPAS2 : neuronal PAS domain-containing protein 2 nationallicence ob/ob mice : genetic model of leptin deficiency caused by a mutation in the gene (ob) nationallicence mice eat excessively and become obese nationallicence PER : period nationallicence family of genes PER1, PER2, and PER3 nationallicence PROK2 : prokineticin 2 nationallicence REM sleep : rapid eye movement sleep nationallicence Shaker : a putative potassium channel gene from Drosophila nationallicence Sleepless : encodes a brain-enriched, glycosylphosphatidylinositol-anchored protein in Drosophila nationallicence Somnologie - Schlafforschung und Schlafmedizin Springer-Verlag 17/1(2013-03-01), 15-20 1432-9123 17:1<15 2013 17 11818 https://doi.org/10.1007/s11818-012-0599-0 text/html Onlinezugriff via DOI 1 article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11818-012-0599-0 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Allebrandt K.V. Institute of Medical Psychology, Medical Faculty, Ludwig-Maximilians-University, Goethestr. 31, 80336, Munich, Germany aut NATIONALLICENCE 773 0- Somnologie - Schlafforschung und Schlafmedizin Springer-Verlag 17/1(2013-03-01), 15-20 1432-9123 17:1<15 2013 17 11818 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer