naa a22 4500 510769322 CHVBK 20180411083208.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s11818-013-0601-5 doi (NATIONALLICENCE)springer-10.1007/s11818-013-0601-5 Mayer G. E-mail: geert.mayer@hephata.com aut Kleine-Levin syndrome [Elektronische Daten] Long-term treatment of 15 German patients [G. Mayer] Kleine-Levin-Syndrom Langzeitbehandlung 15 deutscher Patienten Kleine-Levin syndrome (KLS) is a rare sleep disorder. Most of the published studies have included only small numbers of patients. Therapeutic and diagnostic studies have the lowest evidence level. This study is a retrospective study including 15 KLS patients of the past 19 years. The patients had first symptoms in their early teens triggered by sleep deprivation, infections, and alcohol intake. Frequency ranged from 2-16/year, duration from 1-6weeks. Liver enzymes, blood count, inflammatory markers, and magnetic resonance images were normal in all patients. Cerebral spinal fluid (CSF) hypocretin-1 was assessed in 6patients. It was at the lower normal range in 2patients and < 130pg/ml in 2 other patients during an asymptomatic phase, while it was low in 2patients (96-123pg/ml) and normal in another patient during a symptomatic phase. Treatment with lithium was established in almost all patients and resulted in marked reduction or cessation of symptomatic episodes. The longest observation was 19 years with a relapse after cessation of lithium. Assessment of CSF hypocretin-1 during and outside of a symptomatic phase is recommended in the diagnostic workup of KLS; however, so far only the clinical course is helpful in establishing the diagnosis. Early treatment is recommended and has been found to be effective in the long course of the disease. Springer-Verlag Berlin Heidelberg, 2013 Kleine-Levin syndrome nationallicence Hypersomnia nationallicence Hypocretin-1 nationallicence Lithium treatment nationallicence Disorders of excessive somnolence nationallicence Kleine-Levin-Syndrom nationallicence Hypersomnie nationallicence Hypocretin-1 im Liquor nationallicence Lithiumbehandlung nationallicence Störungen mit exzessiver Schläfrigkeit nationallicence Somnologie - Schlafforschung und Schlafmedizin Springer-Verlag 17/1(2013-03-01), 34-38 1432-9123 17:1<34 2013 17 11818 https://doi.org/10.1007/s11818-013-0601-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11818-013-0601-5 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Mayer G. E-mail: geert.mayer@hephata.com aut NATIONALLICENCE 773 0- Somnologie - Schlafforschung und Schlafmedizin Springer-Verlag 17/1(2013-03-01), 34-38 1432-9123 17:1<34 2013 17 11818 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer