naa a22 4500 510769551 CHVBK 20180411083208.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s11818-013-0622-0 doi (NATIONALLICENCE)springer-10.1007/s11818-013-0622-0 Periodic leg movements during sleep in PLMD and RLS patients with and without pramipexole treatment [Elektronische Daten] [C. Thiedemann, S. Bunten, S. Happe] Periodische Beinbewegungen bei PMLD- und RLS-Patienten mit und ohne Pramipexoltherapie Objective: Pharmacological treatment of restless legs syndrome (RLS) patients with pramipexole (PPX) is common and evidence based, whereas the effect of pramipexole on periodic leg movements (PLM) in periodic limb movement disorder (PLMD) patients is unknown. The aim of this study was to investigate the effect of pramipexole on sleep parameters and PLM indices in RLS and in PLMD patients. Material and methods: Retrospectively, data of two consecutive polysomnographies of 47patients (20women, 27men; mean age 59.8 ± 13.6years; range 23-87years) with RLS (n = 29) or PLMD (n = 18) were analyzed. Of these, 15patients with RLS and 9patients with PLMD were treated with 0.18mg pramipexole directly before the second polysomnographic night. Results: The PLMS (total PML during sleep) index of PLMD patients was significantly higher (p = 0.007) in untreated as well in treated patients (p = 0.007) as compared to RLS. It was significantly reduced (p < 0.03) in both groups under PPX. In RLS + PPX as well as in PLMD + PPX, light sleep significantly increased and deep sleep significantly decreased. The parameters total sleep time (TST) and sleep efficiency showed no significant changes as compared to the first polysomnographic night. Conclusion: Results of this retrospective study indicate that a single treatment with 0.18mg pramipexole leads, on the one hand, to a reduction of PLM indices in sleep both in RLS and in PLMD patients but, on the other hand, to an increase of sleep stages1 and 2 and to a decrease of deep sleep. Springer-Verlag Berlin Heidelberg, 2013 Restless legs syndrome nationallicence Periodic limb movement disorder nationallicence Pharmacologic treatment nationallicence Pramipexole nationallicence Dopamine agonist nationallicence Restless-Legs-Syndrom nationallicence Syndrom der periodischen Beinbewegungen nationallicence Pharmakologische Behandlung nationallicence Pramipexol nationallicence Dopaminagonist nationallicence Thiedemann C. Department of Clinical Neurophysiology, Klinikum Bremen-Ost/University of Göttingen, Bremen, Germany aut Bunten S. Department of Clinical Neurophysiology, Klinikum Bremen-Ost/University of Göttingen, Bremen, Germany aut Happe S. Department of Clinical Neurophysiology, Klinikum Bremen-Ost/University of Göttingen, Bremen, Germany aut Somnologie - Schlafforschung und Schlafmedizin Springer Berlin Heidelberg 17/4(2013-12-01), 266-270 1432-9123 17:4<266 2013 17 11818 https://doi.org/10.1007/s11818-013-0622-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11818-013-0622-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Thiedemann C. Department of Clinical Neurophysiology, Klinikum Bremen-Ost/University of Göttingen, Bremen, Germany aut NATIONALLICENCE 700 1- Bunten S. Department of Clinical Neurophysiology, Klinikum Bremen-Ost/University of Göttingen, Bremen, Germany aut NATIONALLICENCE 700 1- Happe S. Department of Clinical Neurophysiology, Klinikum Bremen-Ost/University of Göttingen, Bremen, Germany aut NATIONALLICENCE 773 0- Somnologie - Schlafforschung und Schlafmedizin Springer Berlin Heidelberg 17/4(2013-12-01), 266-270 1432-9123 17:4<266 2013 17 11818 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer