naa a22 4500 51076956X CHVBK 20180411083208.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s11818-013-0610-4 doi (NATIONALLICENCE)springer-10.1007/s11818-013-0610-4 Effects of cued and contextual fear on sleep in DBA/2J mice [Elektronische Daten] [L. Yang, X. Tang, L.D. Sanford] Effekte von auslöser- und kontextbedingter Angst bei DBA/2J-Mäusen Fear conditioning alters sleep, with the most consistent effect being significant reductions in rapid eye movement sleep (REM). DBA/2 (D2) mice show behavioral signs of anxiety, respond greater to shock training, and potentially behave differently in cued and contextual fear, raising the question of how fear conditioning would affect their sleep. D2 mice were implanted to record sleep via telemetry. After baseline sleep recording, groups of D2 mice were trained in cued (15tone-shock pairings) and contextual (15non-cued shocks) fear on 4consecutive days. Cue and context control mice were given identical training but were never presented with shock. Sleep was recorded after shock training and after presentation of cue or context alone. Shock training produced selective suppression of REM. On the day after shock training was completed, light period sleep was significantly altered in mice in the cued fear group, but not in the contextual fear group. Subsequent presentation of fearful cues and re-exposure to the fearful contexts also produced significant reductions in REM. The effects of fear conditioning on sleep in D2 mice and other mouse strains and the differential effects of cued and contextual fear on sleep are discussed. Springer-Verlag Berlin Heidelberg, 2013 Conditioned fear nationallicence Inbred strain nationallicence Non-rapid eye movement sleep nationallicence Rapid eye movement sleep nationallicence Konditionierte Angst nationallicence Inzuchtmausstämme nationallicence Non-REM-Schlaf nationallicence REM-Schlaf nationallicence Yang L. Sleep Medicine Center, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China aut Tang X. Sleep Medicine Center, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China aut Sanford L.D. Sleep Research Laboratory, Department of Pathology and Anatomy, Eastern Virginia Medical School, 23501, Norfolk, VA, USA aut Somnologie - Schlafforschung und Schlafmedizin Springer-Verlag 17/2(2013-06-01), 80-89 1432-9123 17:2<80 2013 17 11818 https://doi.org/10.1007/s11818-013-0610-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11818-013-0610-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yang L. Sleep Medicine Center, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China aut NATIONALLICENCE 700 1- Tang X. Sleep Medicine Center, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China aut NATIONALLICENCE 700 1- Sanford L.D. Sleep Research Laboratory, Department of Pathology and Anatomy, Eastern Virginia Medical School, 23501, Norfolk, VA, USA aut NATIONALLICENCE 773 0- Somnologie - Schlafforschung und Schlafmedizin Springer-Verlag 17/2(2013-06-01), 80-89 1432-9123 17:2<80 2013 17 11818 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer