naa a22 4500 510769659 CHVBK 20180411083209.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s11818-013-0619-8 doi (NATIONALLICENCE)springer-10.1007/s11818-013-0619-8 Increased incidence of narcolepsy following the 2009 H1N1 pandemic [Elektronische Daten] [X.Z. Zhang, T. Penzel, F. Han] Erhöhte Narkolepsieinzidenz nach der H1N1-Pandemie 2009 Narcolepsy is an autoimmune sleep disease characterized by excessive daytime sleepiness, cataplexy, and intrusive rapid eye movement sleep. Deficit in endogenous orexin is a major pathogenic component of the disease. This disorder is also associated with the gene marker HLADQB1*0602. After the 2009, H1N1 pandemic, a remarkable increased incidence of narcolepsy, especially in children, was noticed in different countries. In Finland and Sweden, this was attributed to the H1N1 vaccine, especially the adjuvanted pandemic vaccines. In China, there was a 3-fold increase in narcolepsy onset but was due to H1N1 virus infection per se. This review will first summarize the epidemiological data of post H1N1 narcolepsy, then possible mechanisms of the H1N1-related immune process to link the HLA (human leukocyte antigen) genetic background and hypocretin deficiency in narcolepsy-cataplexy will be discussed. Springer-Verlag Berlin Heidelberg, 2013 Vaccines nationallicence Incidence nationallicence Influenza A, H1N1 subtype nationallicence Orexins nationallicence HLA antigens nationallicence Impfstoffe nationallicence Inzidenz nationallicence InfluenzaA, Subtyp H1N1 nationallicence Orexine nationallicence HLA-Antigene nationallicence Zhang X.Z. Department of Pulmonary Medicine, Peking University People's Hospital, Beijing, China aut Penzel T. Sleep Medicine Center, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany aut Han F. Department of Pulmonary Medicine, Peking University People's Hospital, Beijing, China aut Somnologie - Schlafforschung und Schlafmedizin Springer-Verlag 17/2(2013-06-01), 90-93 1432-9123 17:2<90 2013 17 11818 https://doi.org/10.1007/s11818-013-0619-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11818-013-0619-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhang X.Z. Department of Pulmonary Medicine, Peking University People's Hospital, Beijing, China aut NATIONALLICENCE 700 1- Penzel T. Sleep Medicine Center, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany aut NATIONALLICENCE 700 1- Han F. Department of Pulmonary Medicine, Peking University People's Hospital, Beijing, China aut NATIONALLICENCE 773 0- Somnologie - Schlafforschung und Schlafmedizin Springer-Verlag 17/2(2013-06-01), 90-93 1432-9123 17:2<90 2013 17 11818 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer