naa a22 4500 510771475 CHVBK 20180411083215.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s11837-013-0575-6 doi (NATIONALLICENCE)springer-10.1007/s11837-013-0575-6 Hydrogel Composite Materials for Tissue Engineering Scaffolds [Elektronische Daten] [Jenna Shapiro, Michelle Oyen] Hydrogels are appealing for biomaterials applications due to their compositional similarity with highly hydrated natural biological tissues. However, for structurally demanding tissue engineering applications, hydrogel use is limited by poor mechanical properties. Here, composite materials approaches are considered for improving hydrogel properties while attempting to more closely mimic natural biological tissue structures. A variety of composite material microstructures is explored, based on multiple hydrogel constituents, particle reinforcement, electrospun nanometer to micrometer diameter polymer fibers with single and multiple fiber networks, and combinations of these approaches to form fully three-dimensional fiber-reinforced hydrogels. Natural and synthetic polymers are examined for formation of a range of scaffolds and across a range of engineered tissue applications. Following a discussion of the design and fabrication of composite scaffolds, interactions between living biological cells and composite scaffolds are considered across the full life cycle of tissue engineering from scaffold fabrication to in vivo use. We conclude with a summary of progress in this area to date and make recommendations for continuing research and for advanced hydrogel scaffold development. TMS, 2013 Shapiro Jenna Department of Engineering, University of Cambridge, CB2 1PZ, Cambridge, UK aut Oyen Michelle Department of Engineering, University of Cambridge, CB2 1PZ, Cambridge, UK aut JOM Springer US; http://www.springer-ny.com 65/4(2013-04-01), 505-516 1047-4838 65:4<505 2013 65 11837 https://doi.org/10.1007/s11837-013-0575-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11837-013-0575-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shapiro Jenna Department of Engineering, University of Cambridge, CB2 1PZ, Cambridge, UK aut NATIONALLICENCE 700 1- Oyen Michelle Department of Engineering, University of Cambridge, CB2 1PZ, Cambridge, UK aut NATIONALLICENCE 773 0- JOM Springer US; http://www.springer-ny.com 65/4(2013-04-01), 505-516 1047-4838 65:4<505 2013 65 11837 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer