naa a22 4500 510771483 CHVBK 20180411083215.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s11837-013-0574-7 doi (NATIONALLICENCE)springer-10.1007/s11837-013-0574-7 Inkjet Printing of Amphotericin B onto Biodegradable Microneedles Using Piezoelectric Inkjet Printing [Elektronische Daten] [Ryan Boehm, Philip Miller, Wiley Schell, John Perfect, Roger Narayan] The delivery of amphotericin B, a pharmacologic agent with activity against a broad spectrum of fungi as well as against parasitic protozoa, has been complicated by the fact that amphotericin B exhibits poor solubility in aqueous solutions at physiologic pH levels. In this study, piezoelectric inkjet printing was used to modify the surfaces of Gantrez 169 BF microneedles (Ashland, Covington, KY). These amphotericin B-loaded microneedles demonstrated activity against Candida parapsilosis in a radial diffusion assay. The results of this study suggest that a combination of visible light dynamic mask microstereolithography, micromolding, and piezoelectric inkjet printing may be used to prepare amphotericin B-loaded microneedles with antifungal properties. It is envisioned that microneedles containing amphotericin B may be used for transdermal delivery of pharmacologic agents for the treatment of cutaneous fungal infections as well as cutaneous leishmaniasis. TMS, 2013 Boehm Ryan Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, 27695, Raleigh, NC, USA aut Miller Philip Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, 27695, Raleigh, NC, USA aut Schell Wiley Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, 27705, Durham, NC, USA aut Perfect John Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, 27705, Durham, NC, USA aut Narayan Roger Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, 27695, Raleigh, NC, USA aut JOM Springer US; http://www.springer-ny.com 65/4(2013-04-01), 525-533 1047-4838 65:4<525 2013 65 11837 https://doi.org/10.1007/s11837-013-0574-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11837-013-0574-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Boehm Ryan Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, 27695, Raleigh, NC, USA aut NATIONALLICENCE 700 1- Miller Philip Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, 27695, Raleigh, NC, USA aut NATIONALLICENCE 700 1- Schell Wiley Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, 27705, Durham, NC, USA aut NATIONALLICENCE 700 1- Perfect John Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, 27705, Durham, NC, USA aut NATIONALLICENCE 700 1- Narayan Roger Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, 27695, Raleigh, NC, USA aut NATIONALLICENCE 773 0- JOM Springer US; http://www.springer-ny.com 65/4(2013-04-01), 525-533 1047-4838 65:4<525 2013 65 11837 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer