naa a22 4500 510771548 CHVBK 20180411083216.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s11837-013-0565-8 doi (NATIONALLICENCE)springer-10.1007/s11837-013-0565-8 Prevention of Ultraviolet (UV)-Induced Surface Damage and Cytotoxicity of Polyethersulfone Using Atomic Layer Deposition (ALD) Titanium Dioxide [Elektronische Daten] [Peter Petrochenko, Giovanna Scarel, G. Hyde, Gregory Parsons, Shelby Skoog, Qin Zhang, Peter Goering, Roger Narayan] Nanostructured surfaces are finding use in several medical applications, including tissue scaffolds and wound dressings. These surfaces are frequently manufactured from biocompatible polymers that are susceptible to ultraviolet (UV) damage. Polyethersulfone (PES) is a biocompatible polymer that undergoes oxidation and degradation when exposed to ultraviolet (UV) light. A uniform TiO2 coating can protect PES during exposure to UV sources (e.g., germicidal lamps and sunlight). The goal of this study was to determine whether atomic layer deposition (ALD) can successfully be used to grow TiO2 onto PES, protect it from UV irradiation, and reduce macrophage in vitro cytotoxicity. TiO2 was ALD-coated onto PES at 21nm thickness. Uncoated PES exposed to UV for 30min visibly changed color, whereas TiO2-coated PES showed no color change, indicating limited degradation. Macrophages exposed to UV-treated PES for 48h showed reduced cell viability (via MTT assay) to 18% of control. In contrast, the cell viability for UV-treated TiO2-coated PES was 90% of control. Non-UV treated PES showed no decrease in cell viability. The results indicate that ALD of TiO2 thin films is a useful technique to protect polymers from UV damage and to retain low cytotoxicity to macrophages and other types of cells that are involved in wound healing. TiO2- coated PES membranes also have potential use in direct methanol fuel cells and in wastewater treatment membranes. TMS, 2013 Petrochenko Peter Division of Biology, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD, USA aut Scarel Giovanna Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC, USA aut Hyde G. Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC, USA aut Parsons Gregory Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC, USA aut Skoog Shelby Division of Biology, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD, USA aut Zhang Qin Division of Biology, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD, USA aut Goering Peter Division of Biology, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD, USA aut Narayan Roger Joint Department of Biomedical Engineering, UNC—Chapel Hill and North Carolina State University, Raleigh, NC, USA aut JOM Springer US; http://www.springer-ny.com 65/4(2013-04-01), 550-556 1047-4838 65:4<550 2013 65 11837 https://doi.org/10.1007/s11837-013-0565-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11837-013-0565-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Petrochenko Peter Division of Biology, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD, USA aut NATIONALLICENCE 700 1- Scarel Giovanna Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC, USA aut NATIONALLICENCE 700 1- Hyde G. Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC, USA aut NATIONALLICENCE 700 1- Parsons Gregory Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC, USA aut NATIONALLICENCE 700 1- Skoog Shelby Division of Biology, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD, USA aut NATIONALLICENCE 700 1- Zhang Qin Division of Biology, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD, USA aut NATIONALLICENCE 700 1- Goering Peter Division of Biology, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD, USA aut NATIONALLICENCE 700 1- Narayan Roger Joint Department of Biomedical Engineering, UNC—Chapel Hill and North Carolina State University, Raleigh, NC, USA aut NATIONALLICENCE 773 0- JOM Springer US; http://www.springer-ny.com 65/4(2013-04-01), 550-556 1047-4838 65:4<550 2013 65 11837 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer