naa a22 4500 51077329X CHVBK 20180411083221.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s12022-012-9227-6 doi (NATIONALLICENCE)springer-10.1007/s12022-012-9227-6 Follicular Thyroid Carcinoma Presenting as a Massive Chest Wall Tumor [Elektronische Daten] [Ryan Gertz, Rakesh Sarda, Ricardo Lloyd] The initial presentation of follicular thyroid carcinoma is rarely related to metastatic lesions. Presented here is the case of a 70-year-old woman with the initial presentation of a 13-cm chest wall mass identified as a metastatic follicular thyroid carcinoma. The chest wall lesion had features of a poorly differentiated carcinoma with areas of necrosis, an insular growth pattern focally and increased mitotic activity. A small follicular carcinoma was subsequently identified. The primary tumor was a 1-cm well-differentiated follicular carcinoma with capsular and vascular invasion. This represents a rare presentation of a follicular thyroid carcinoma with initial recognition of a large, dedifferentiated metastatic lesion from a small primary carcinoma. Dedifferentiation and metastasis in the context of microcarcinoma is an exceptionally rare event and suggests other mechanisms may be involved in disease spread other than simply increased cell proliferation. Springer Science+Business Media New York, 2012 Follicular thyroid carcinoma nationallicence Distant metastases nationallicence Poorly differentiated thyroid carcinoma nationallicence Dedifferentiation nationallicence Chest wall metastasis nationallicence Gertz Ryan Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 600 Highland Avenue, 53792, Madison, WI, USA aut Sarda Rakesh Department of Pathology, Meriter Hospital, 36 South Brooks Street, 53715, Madison, WI, USA aut Lloyd Ricardo Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 600 Highland Avenue, 53792, Madison, WI, USA aut Endocrine Pathology Springer US; http://www.springer-ny.com 24/1(2013-03-01), 20-24 1046-3976 24:1<20 2013 24 12022 https://doi.org/10.1007/s12022-012-9227-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12022-012-9227-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gertz Ryan Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 600 Highland Avenue, 53792, Madison, WI, USA aut NATIONALLICENCE 700 1- Sarda Rakesh Department of Pathology, Meriter Hospital, 36 South Brooks Street, 53715, Madison, WI, USA aut NATIONALLICENCE 700 1- Lloyd Ricardo Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 600 Highland Avenue, 53792, Madison, WI, USA aut NATIONALLICENCE 773 0- Endocrine Pathology Springer US; http://www.springer-ny.com 24/1(2013-03-01), 20-24 1046-3976 24:1<20 2013 24 12022 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer