naa a22 4500 51077332X CHVBK 20180411083221.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s12022-013-9235-1 doi (NATIONALLICENCE)springer-10.1007/s12022-013-9235-1 Stem Cells and Cancer Stem-Like Cells in Endocrine Tissues [Elektronische Daten] [Ricardo Lloyd, Heather Hardin, Celina Montemayor-Garcia, Fabio Rotondo, Luis Syro, Eva Horvath, Kalman Kovacs] Cancer stem-like cells are a subpopulation of self-renewing cells that are more resistant to chemotherapy and radiation therapy than the other surrounding cancer cells. The cancer stem cell model predicts that only a subset of cancer cells possess the ability to self-renew and produce progenitor cells that can reconstitute and sustain tumor growth. Evidence supporting the existence of cancer stem-like cells in the thyroid, pituitary, and in other endocrine tissues is rapidly accumulating. These cells have been studied using specific biomarkers including: CD133, CD44, Nestin, Nanog, and aldehyde dehydrogenase enzyme. Putative cancer stem-like cells can be studied in vitro using serum-free media supplemented with basic fibroblast growth factor and epidermal growth factor grown in low attachment plates or in extracellular matrix leading to sphere formation in vitro. Cancer stem-like cells can also be separated by fluorescent cell sorting and used for in vitro or in vivo studies. Injection of enriched populations of cancer stem-like cells (also referred to as tumor initiating cells) into immunodeficient mice results in growth of xenografts which express cancer stem-like biomarkers. Human cancer stem-like cells have been identified in thyroid cancer cell lines, in primary thyroid cancers, in normal pituitary, and in pituitary tumors. Other recent studies suggest the existence of stem cells and cancer stem-like cells in endocrine tumors of the gastrointestinal tract, pancreas, lungs, adrenal, parathyroid, and skin. New discoveries in this field may lead to more effective therapies for highly aggressive and lethal endocrine cancers. Springer Science+Business Media New York, 2013 Cancer stem-like cells nationallicence Thyroid nationallicence Pituitary nationallicence Carcinoid nationallicence Adrenal cortex nationallicence Parathyroid nationallicence Lloyd Ricardo Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, K4/436 CSC 8550, 53705, Madison, WI, USA aut Hardin Heather Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, K4/436 CSC 8550, 53705, Madison, WI, USA aut Montemayor-Garcia Celina Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, K4/436 CSC 8550, 53705, Madison, WI, USA aut Rotondo Fabio Division of Pathology, St. Michael's Hospital, University of Toronto, Ontario, CA, USA aut Syro Luis Division of Pathology, St. Michael's Hospital, University of Toronto, Ontario, CA, USA aut Horvath Eva Division of Pathology, St. Michael's Hospital, University of Toronto, Ontario, CA, USA aut Kovacs Kalman Division of Pathology, St. Michael's Hospital, University of Toronto, Ontario, CA, USA aut Endocrine Pathology Springer US; http://www.springer-ny.com 24/1(2013-03-01), 1-10 1046-3976 24:1<1 2013 24 12022 https://doi.org/10.1007/s12022-013-9235-1 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12022-013-9235-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lloyd Ricardo Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, K4/436 CSC 8550, 53705, Madison, WI, USA aut NATIONALLICENCE 700 1- Hardin Heather Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, K4/436 CSC 8550, 53705, Madison, WI, USA aut NATIONALLICENCE 700 1- Montemayor-Garcia Celina Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, K4/436 CSC 8550, 53705, Madison, WI, USA aut NATIONALLICENCE 700 1- Rotondo Fabio Division of Pathology, St. Michael's Hospital, University of Toronto, Ontario, CA, USA aut NATIONALLICENCE 700 1- Syro Luis Division of Pathology, St. Michael's Hospital, University of Toronto, Ontario, CA, USA aut NATIONALLICENCE 700 1- Horvath Eva Division of Pathology, St. Michael's Hospital, University of Toronto, Ontario, CA, USA aut NATIONALLICENCE 700 1- Kovacs Kalman Division of Pathology, St. Michael's Hospital, University of Toronto, Ontario, CA, USA aut NATIONALLICENCE 773 0- Endocrine Pathology Springer US; http://www.springer-ny.com 24/1(2013-03-01), 1-10 1046-3976 24:1<1 2013 24 12022 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer