naa a22 4500 510773389 CHVBK 20180411083222.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s12022-013-9256-9 doi (NATIONALLICENCE)springer-10.1007/s12022-013-9256-9 Silent Corticotroph Adenoma with Adrenal Cortical Choristoma: a Rare but Distinct Morphological Entity [Elektronische Daten] [Ozgur Mete, Thomas Ng, Darshika Christie-David, Jacqueline McMaster, Sylvia Asa] This report describes a case of pituitary adenoma with interspersed adrenal cortical cells. The pituitary cells were confirmed to be corticotrophs with Tpit and adrenocorticotropic hormone immunohistochemistry, whereas the adrenal cortical cells were verified to be such with steroidogenic factor-1 (SF-1), inhibin, calretinin, and Melan A staining. The presence of normal adrenal cortical cells in the heterotopic location of the sella fulfills the definition of choristoma. The origin of adrenal cortical cells within a pituitary adenoma remains unexplained. The important role of SF-1 in both pituitary and adrenal cortex may explain a relationship that supports the possibility of an abnormal proliferation and differentiation of uncommitted mesenchymal stem cells within the sella. However, it remains possible that misplaced adrenal cortical cells derived during embryogenesis give rise to this rare but distinct morphological entity that can pose a difficult diagnostic dilemma. The approach to differential diagnosis is discussed. Springer Science+Business Media New York, 2013 Choristoma nationallicence Silent corticotroph adenoma nationallicence Adrenal cortical heterotopia nationallicence Steroidogenic factor-1 nationallicence Mete Ozgur Department of Pathology, University Health Network, 200 Elizabeth Street, 11th floor, M5G 2C4, Toronto, ON, Canada aut Ng Thomas Institute of Clinical Pathology and Medical Research, Tissue Pathology and Diagnostic Oncology, Westmead Hospital, University of Western Sydney, Sydney, Westmead, Australia aut Christie-David Darshika Department of Diabetes and Endocrinology, Westmead Hospital, University of Sydney, Sydney, NSW, Australia aut McMaster Jacqueline Department of Neurosurgery, Westmead Hospital, Sydney, NSW, Australia aut Asa Sylvia Department of Pathology, University Health Network, 200 Elizabeth Street, 11th floor, M5G 2C4, Toronto, ON, Canada aut Endocrine Pathology Springer US; http://www.springer-ny.com 24/3(2013-09-01), 162-166 1046-3976 24:3<162 2013 24 12022 https://doi.org/10.1007/s12022-013-9256-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12022-013-9256-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mete Ozgur Department of Pathology, University Health Network, 200 Elizabeth Street, 11th floor, M5G 2C4, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Ng Thomas Institute of Clinical Pathology and Medical Research, Tissue Pathology and Diagnostic Oncology, Westmead Hospital, University of Western Sydney, Sydney, Westmead, Australia aut NATIONALLICENCE 700 1- Christie-David Darshika Department of Diabetes and Endocrinology, Westmead Hospital, University of Sydney, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- McMaster Jacqueline Department of Neurosurgery, Westmead Hospital, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Asa Sylvia Department of Pathology, University Health Network, 200 Elizabeth Street, 11th floor, M5G 2C4, Toronto, ON, Canada aut NATIONALLICENCE 773 0- Endocrine Pathology Springer US; http://www.springer-ny.com 24/3(2013-09-01), 162-166 1046-3976 24:3<162 2013 24 12022 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer