naa a22 4500 510773419 CHVBK 20180411083222.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s12022-013-9254-y doi (NATIONALLICENCE)springer-10.1007/s12022-013-9254-y Pituicytoma with Gelsolin Amyloid Deposition [Elektronische Daten] [Cristiane Ida, Xiaoling Yan, Mark Jentoft, N. Kip, Bernd Scheithauer, Jonathan Morris, Ahmet Dogan, Joseph Parisi, Kalman Kovacs] Pituicytoma is a rare low-grade (WHO grade I) sellar region glioma. Among sellar tumors, pituitary adenomas, mainly prolactinomas, may show amyloid deposits. Gelsolin is a ubiquitous calcium-dependent protein that regulates actin filament dynamics. Two known gene point mutations result in gelsolin amyloid deposition, a characteristic feature of a rare type of familial amyloid polyneuropathy (FAP), the Finnish-type FAP, or hereditary gelsolin amyloidosis (HGA). HGA is an autosomal-dominant systemic amyloidosis, characterized by slowly progressive neurological deterioration with corneal lattice dystrophy, cranial neuropathy, and cutis laxa. A unique case of pituicytoma with marked gelsolin amyloid deposition in a 67-year-old Chinese woman is described. MRI revealed a 2.6-cm well-circumscribed, uniformly contrast-enhancing solid sellar mass with suprasellar extension. Histologically, the lesion was characterized by solid sheets and fascicles of spindle cells with slightly fibrillary cytoplasm and oval nuclei with pinpoint nucleoli. Surrounding brain parenchyma showed marked reactive piloid gliosis. Remarkably, conspicuous amyloid deposits were identified as pink homogeneous spherules on light microscopy that showed apple-green birefringence on Congo red with polarization. Mass spectrometric-based proteomic analysis identified the amyloid as gelsolin type. Immunohistochemically, diffuse reactivity to S100 protein and TTF1, focal reactivity for GFAP, and no reactivity to EMA, synaptophysin, and chromogranin were observed. HGA-related mutations were not identified in the tumor. No recurrence was noted 14months after surgery. To the knowledge of the authors, amyloid deposition in pituicytoma or tumor-associated gelsolin amyloidosis has not been previously described. This novel finding expands the spectrum of sellar tumors that may be associated with amyloid deposition. Springer Science+Business Media New York, 2013 Pituicytoma nationallicence Gelsolin nationallicence Amyloid nationallicence Pituitary nationallicence Adenoma nationallicence Ida Cristiane Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, 55905, Rochester, MN, USA aut Yan Xiaoling Department of Pathology, Tianjin HuanHu Hospital, Tianjin, China aut Jentoft Mark Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, 55905, Rochester, MN, USA aut Kip N. Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, 55905, Rochester, MN, USA aut Scheithauer Bernd Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, 55905, Rochester, MN, USA aut Morris Jonathan Department of Radiology, Mayo Clinic, Rochester, MN, USA aut Dogan Ahmet Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, 55905, Rochester, MN, USA aut Parisi Joseph Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, 55905, Rochester, MN, USA aut Kovacs Kalman Department of Pathology, St. Michael's Hospital, Toronto, ON, Canada aut Endocrine Pathology Springer US; http://www.springer-ny.com 24/3(2013-09-01), 149-155 1046-3976 24:3<149 2013 24 12022 https://doi.org/10.1007/s12022-013-9254-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12022-013-9254-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ida Cristiane Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Yan Xiaoling Department of Pathology, Tianjin HuanHu Hospital, Tianjin, China aut NATIONALLICENCE 700 1- Jentoft Mark Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Kip N. Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Scheithauer Bernd Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Morris Jonathan Department of Radiology, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Dogan Ahmet Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Parisi Joseph Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Kovacs Kalman Department of Pathology, St. Michael's Hospital, Toronto, ON, Canada aut NATIONALLICENCE 773 0- Endocrine Pathology Springer US; http://www.springer-ny.com 24/3(2013-09-01), 149-155 1046-3976 24:3<149 2013 24 12022 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer