naa a22 4500 510773435 CHVBK 20180411083222.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s12022-013-9248-9 doi (NATIONALLICENCE)springer-10.1007/s12022-013-9248-9 Undifferentiated (Anaplastic) Thyroid Carcinoma and Iodine Intake in Salta, Argentina [Elektronische Daten] [H. Harach, Macarena Galíndez, Mónica Campero, G. Ceballos] This study was conducted to investigate the natural history of undifferentiated thyroid carcinoma (UTC) in the iodine-deficient province of Salta, Argentina, in relation to salt iodization and health care standards. Five hundred ninety-three thyroid cancers diagnosed from 1958 to2012 were reviewed based mainly on the WHO classification and grouped into three periods, one before and two after iodine prophylaxis. The incidence of UTC was analyzed in relation to changing concentrations of potassium iodide (KI) in salt during the prophylaxis period (from 40 to 33.3mg KI/kg salt), establishment of primary health care centers throughout the region, and use of fine needle aspiration (FNA) cytology. Twenty-nine UTCs were found in the whole series. The frequency of UTC decreased from 15.2% (9/59 cases) in the first period to 2.6% (10/381 cases) well after salt iodination (x 2 Fisher's test, p < 0.0002), and the incidence from 1.4/106/year to 0.1/106/year (Student's t test, p < 0.06), respectively. The decline of UTC after iodine prophylaxis occurred even after decreasing concentrations of KI in salt and timely coincided with the establishment of primary health care centers throughout the region and routine use of FNA. The lower rate of UTC after iodine prophylaxis in the province of Salta is mostly related to earlier detection of more differentiated thyroid tumors rather than higher salt iodization. Springer Science+Business Media New York, 2013 Thyroid nationallicence Undifferentiated carcinoma nationallicence Iodine nationallicence Endemic goiter nationallicence Harach H. Pathology Unit, "Dr. A. Oñativia” Hospital, Salta, Argentina aut Galíndez Macarena Department of Endocrinology, "Dr. A. Oñativia” Hospital, Salta, Argentina aut Campero Mónica Department of Diabetes and Nutrition, "Dr. A. Oñativia” Hospital, Salta, Argentina aut Ceballos G. Department of Surgery, "Dr. A. Oñativia” Hospital, Salta, Argentina aut Endocrine Pathology Springer US; http://www.springer-ny.com 24/3(2013-09-01), 125-131 1046-3976 24:3<125 2013 24 12022 https://doi.org/10.1007/s12022-013-9248-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12022-013-9248-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Harach H. Pathology Unit, "Dr. A. Oñativia” Hospital, Salta, Argentina aut NATIONALLICENCE 700 1- Galíndez Macarena Department of Endocrinology, "Dr. A. Oñativia” Hospital, Salta, Argentina aut NATIONALLICENCE 700 1- Campero Mónica Department of Diabetes and Nutrition, "Dr. A. Oñativia” Hospital, Salta, Argentina aut NATIONALLICENCE 700 1- Ceballos G. Department of Surgery, "Dr. A. Oñativia” Hospital, Salta, Argentina aut NATIONALLICENCE 773 0- Endocrine Pathology Springer US; http://www.springer-ny.com 24/3(2013-09-01), 125-131 1046-3976 24:3<125 2013 24 12022 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer