naa a22 4500 510773443 CHVBK 20180411083222.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s12022-013-9257-8 doi (NATIONALLICENCE)springer-10.1007/s12022-013-9257-8 Metastatic Carcinoma to the Thyroid Gland: A Single Institution 20-Year Experience and Review of the Literature [Elektronische Daten] [Parnian Moghaddam, Kristine Cornejo, Ashraf Khan] The thyroid gland is an uncommon site for metastatic disease but cases have been well-documented in the literature, particularly in autopsy series. A retrospective review of surgical pathology and autopsy pathology database for patients with metastatic carcinoma to the thyroid was performed at the University of Massachusetts Medical Center between January 1993 to January 2013. We identified a total of 10 patients with metastatic carcinoma to the thyroid; 6 were in surgical pathology specimens out of a total of 1,295 thyroid carcinoma (0.46%) and 4 were diagnosed at autopsy out of a total of 2,117 (0.19%) autopsy cases during this period. Cases with direct extension of the tumor into the thyroid from local primary sites such as larynx, esophagus or soft tissues of the neck were excluded. The primary tumors in these cases comprised of four lung carcinomas, three colorectal carcinomas, a renal cell carcinoma, a pleural malignant mesothelioma, and an unknown primary. Therefore, it is important to keep intrathyroidal metastases in the differential diagnosis when evaluating a thyroid nodule, particularly in patients with a previous history of malignancy. Furthermore, a literature review reveals over 1,400 cases have been previously reported, with the most common malignancies from the kidney (34%), lung (15%), gastrointestinal tract (14%), and breast (14%). Springer Science+Business Media New York, 2013 Metastatic carcinoma nationallicence Intrathyroidal metastasis nationallicence Malignant mesothelioma nationallicence Breast carcinoma nationallicence Lung adenocarcinoma nationallicence Tumor-to-tumor metastasis nationallicence Moghaddam Parnian Department of Pathology, University of Massachusetts Medical School, Biotech 3, One Innovation Drive, 01605, Worcester, MA, USA aut Cornejo Kristine Department of Pathology, University of Massachusetts Medical School, Biotech 3, One Innovation Drive, 01605, Worcester, MA, USA aut Khan Ashraf Department of Pathology, University of Massachusetts Medical School, Biotech 3, One Innovation Drive, 01605, Worcester, MA, USA aut Endocrine Pathology Springer US; http://www.springer-ny.com 24/3(2013-09-01), 116-124 1046-3976 24:3<116 2013 24 12022 https://doi.org/10.1007/s12022-013-9257-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12022-013-9257-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Moghaddam Parnian Department of Pathology, University of Massachusetts Medical School, Biotech 3, One Innovation Drive, 01605, Worcester, MA, USA aut NATIONALLICENCE 700 1- Cornejo Kristine Department of Pathology, University of Massachusetts Medical School, Biotech 3, One Innovation Drive, 01605, Worcester, MA, USA aut NATIONALLICENCE 700 1- Khan Ashraf Department of Pathology, University of Massachusetts Medical School, Biotech 3, One Innovation Drive, 01605, Worcester, MA, USA aut NATIONALLICENCE 773 0- Endocrine Pathology Springer US; http://www.springer-ny.com 24/3(2013-09-01), 116-124 1046-3976 24:3<116 2013 24 12022 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer