naa a22 4500 51077346X CHVBK 20180411083222.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s12022-013-9259-6 doi (NATIONALLICENCE)springer-10.1007/s12022-013-9259-6 Different CXCR4 Expression According to Various Histologic Subtype of Papillary Thyroid Carcinoma [Elektronische Daten] [Dong Shin, Kwang Kim, Cheol Ku, Mi Lee, Soo Jee, Woong Chung, Eun Lee] Functional chemokine (C-X-C motif) receptor 4 (CXCR4) is well known to be over-expressed in papillary thyroid carcinoma (PTC). The aim of this study was to evaluate whether or not the expression of CXCR4 is different by histological subtypes of PTC and to elucidate the relationship between the expression of CXCR4 and clinicopathologic factors. CXCR4 expression in 127 PTC samples was assessed using immunohistochemical staining. The expression of CXCR4 showed different patterns according to the histological subtype of PTC (p < 0.001). A strong expression of CXCR4 was observed more frequently in the poorly differentiated region of PTC (81.0%) than in classical PTC (50.0%). Strong CXCR4 expression was less frequently shown in follicular variant (33.9%) and in diffuse sclerosing variant (14.3%) of PTC. CXCR4 expression showed a distinct pattern according to the histological subtype of PTC although not associated with other clinicopathological parameters. Springer Science+Business Media New York, 2013 Papillary Thyroid Carcinoma nationallicence CXCR4 nationallicence Chemokine Receptor nationallicence Immunohistochemistry nationallicence Tissue Microarray nationallicence Shin Dong Division of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro Seodaemun-gu, 120-752, Seoul, South Korea aut Kim Kwang Division of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro Seodaemun-gu, 120-752, Seoul, South Korea aut Ku Cheol Division of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro Seodaemun-gu, 120-752, Seoul, South Korea aut Lee Mi Department of Pathology, NHIS Ilsan Hospital, 100 Ilsan-ro Ilsan-donggu, 410-719, Goyang-si, Gyeonggi-do, South Korea aut Jee Soo Department of Pathology, NHIS Ilsan Hospital, 100 Ilsan-ro Ilsan-donggu, 410-719, Goyang-si, Gyeonggi-do, South Korea aut Chung Woong Department of Surgery, Yonsei University College of Medicine, 120-752, Seoul, South Korea aut Lee Eun Division of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro Seodaemun-gu, 120-752, Seoul, South Korea aut Endocrine Pathology Springer US; http://www.springer-ny.com 24/4(2013-12-01), 169-176 1046-3976 24:4<169 2013 24 12022 https://doi.org/10.1007/s12022-013-9259-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12022-013-9259-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shin Dong Division of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro Seodaemun-gu, 120-752, Seoul, South Korea aut NATIONALLICENCE 700 1- Kim Kwang Division of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro Seodaemun-gu, 120-752, Seoul, South Korea aut NATIONALLICENCE 700 1- Ku Cheol Division of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro Seodaemun-gu, 120-752, Seoul, South Korea aut NATIONALLICENCE 700 1- Lee Mi Department of Pathology, NHIS Ilsan Hospital, 100 Ilsan-ro Ilsan-donggu, 410-719, Goyang-si, Gyeonggi-do, South Korea aut NATIONALLICENCE 700 1- Jee Soo Department of Pathology, NHIS Ilsan Hospital, 100 Ilsan-ro Ilsan-donggu, 410-719, Goyang-si, Gyeonggi-do, South Korea aut NATIONALLICENCE 700 1- Chung Woong Department of Surgery, Yonsei University College of Medicine, 120-752, Seoul, South Korea aut NATIONALLICENCE 700 1- Lee Eun Division of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro Seodaemun-gu, 120-752, Seoul, South Korea aut NATIONALLICENCE 773 0- Endocrine Pathology Springer US; http://www.springer-ny.com 24/4(2013-12-01), 169-176 1046-3976 24:4<169 2013 24 12022 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer