naa a22 4500 510773583 CHVBK 20180411083222.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s12022-013-9263-x doi (NATIONALLICENCE)springer-10.1007/s12022-013-9263-x Predictive Factors of Malignancy in Thyroid Nodules with a Cytological Diagnosis of Follicular Neoplasm [Elektronische Daten] [Seong Lee, Jeong Baek, Joo Lee, Jung Lim, Soo Cho, Tae Lee, Yun Ku, Hong Kim, Min Kim] In cases of follicular neoplasm identified by thyroid fine-needle aspiration (FNA), surgery is required to achieve a precise diagnosis. We investigated potential clinical factors for the preoperative prediction of malignancy in thyroid nodules with a cytological diagnosis of follicular neoplasm. We retrospectively reviewed the data of 97 patients who were diagnosed with follicular neoplasm by FNA and had undergone surgery at the Korea Cancer Center Hospital between April 2010 and April 2012. Age, sex, laboratory data (such as thyroid-stimulating hormone, free T4, thyroglobulin (Tg), and Tg antibody), and ultrasonographic findings were reviewed from the electronic medical records. Of 97 patients, 50 (51.5%) were diagnosed with benign nodules, 16 (16.5%) with follicular thyroid carcinoma (FTC), and 31 (32.0%) with papillary thyroid carcinoma (PTC). In comparison with the features of benign nodules, FTC presented with a large nodule size, high serum Tg level, isoechogenicity, calcifications, and peripheral halo, whereas PTC exhibited traits similar to those of benign nodules, except for high serum Tg level and the presence of calcifications on ultrasonography. Therefore, a high serum Tg level (≥75ng/mL) and calcification were the only significant predictive factors for malignancy in case of follicular neoplasm (p < 0.01). Serum Tg levels and the presence of calcification on ultrasonography are important clinical features to predict malignancy in thyroid nodules with cytological diagnosis of follicular neoplasm. Springer Science+Business Media New York, 2013 Thyroid neoplasms nationallicence Thyroid nodule nationallicence Follicular thyroid cancer nationallicence Papillary thyroid cancer nationallicence Fine-needle biopsy nationallicence Lee Seong Department of Internal Medicine, Korea Cancer Center Hospital, 75, Nowon-ro, 139-706, Seoul, Nowon-gu, Republic of Korea aut Baek Jeong Department of Internal Medicine, Korea Cancer Center Hospital, 75, Nowon-ro, 139-706, Seoul, Nowon-gu, Republic of Korea aut Lee Joo Department of Internal Medicine, Korea Cancer Center Hospital, 75, Nowon-ro, 139-706, Seoul, Nowon-gu, Republic of Korea aut Lim Jung Department of Internal Medicine, Eulji University School of Medicine, 139-872, Seoul, Republic of Korea aut Cho Soo Department of Pathology, Korea Cancer Center Hospital, 139-706, Seoul, Republic of Korea aut Lee Tae Department of Radiology, Korea Cancer Center Hospital, 139-706, Seoul, Republic of Korea aut Ku Yun Department of Internal Medicine, Korea Cancer Center Hospital, 75, Nowon-ro, 139-706, Seoul, Nowon-gu, Republic of Korea aut Kim Hong Department of Internal Medicine, Korea Cancer Center Hospital, 75, Nowon-ro, 139-706, Seoul, Nowon-gu, Republic of Korea aut Kim Min Department of Internal Medicine, Korea Cancer Center Hospital, 75, Nowon-ro, 139-706, Seoul, Nowon-gu, Republic of Korea aut Endocrine Pathology Springer US; http://www.springer-ny.com 24/4(2013-12-01), 177-183 1046-3976 24:4<177 2013 24 12022 https://doi.org/10.1007/s12022-013-9263-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12022-013-9263-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lee Seong Department of Internal Medicine, Korea Cancer Center Hospital, 75, Nowon-ro, 139-706, Seoul, Nowon-gu, Republic of Korea aut NATIONALLICENCE 700 1- Baek Jeong Department of Internal Medicine, Korea Cancer Center Hospital, 75, Nowon-ro, 139-706, Seoul, Nowon-gu, Republic of Korea aut NATIONALLICENCE 700 1- Lee Joo Department of Internal Medicine, Korea Cancer Center Hospital, 75, Nowon-ro, 139-706, Seoul, Nowon-gu, Republic of Korea aut NATIONALLICENCE 700 1- Lim Jung Department of Internal Medicine, Eulji University School of Medicine, 139-872, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Cho Soo Department of Pathology, Korea Cancer Center Hospital, 139-706, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Lee Tae Department of Radiology, Korea Cancer Center Hospital, 139-706, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Ku Yun Department of Internal Medicine, Korea Cancer Center Hospital, 75, Nowon-ro, 139-706, Seoul, Nowon-gu, Republic of Korea aut NATIONALLICENCE 700 1- Kim Hong Department of Internal Medicine, Korea Cancer Center Hospital, 75, Nowon-ro, 139-706, Seoul, Nowon-gu, Republic of Korea aut NATIONALLICENCE 700 1- Kim Min Department of Internal Medicine, Korea Cancer Center Hospital, 75, Nowon-ro, 139-706, Seoul, Nowon-gu, Republic of Korea aut NATIONALLICENCE 773 0- Endocrine Pathology Springer US; http://www.springer-ny.com 24/4(2013-12-01), 177-183 1046-3976 24:4<177 2013 24 12022 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer