naa a22 4500 510773605 CHVBK 20180411083223.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12022-013-9237-z doi (NATIONALLICENCE)springer-10.1007/s12022-013-9237-z Double, Synchronous Pituitary Adenomas Causing Acromegaly and Cushing's Disease. A Case Report and Review of Literature [Elektronische Daten] [Grzegorz Zieliński, Maria Maksymowicz, Jan Podgórski, Włodzimierz Olszewski] Double pituitary adenomas are very rare and present up to 1% of pituitary adenomas in unselected autopsy series and up to 2% in large surgical series. We report a case of a 47-year-old man presented slight clinical features of acromegaly with 2years duration. Endocrine evaluation confirmed active acromegaly and revealed adrenocorticotropin hormone-dependent hypercortisolemia. Preoperative magnetic resonance imaging of the pituitary demonstrated clearly separated double microadenomas with different intensity. The patient underwent transsphenoidal surgery and both tumors were completely removed and were fixed separately. The histological and ultrastructural examination confirmed coincidence of the double, clearly separated pituitary adenomas in one gland. Postoperative function of the hypothalamo-hypophyseal axis was normalized. We conclude from this case and a literature review that double endocrinologically active pituitary adenomas leading to acromegaly and Cushing's disease may occur. Additionally, a review of the literature regarding multiple pituitary adenomas has also been performed. The Author(s), 2013 Double pituitary adenoma nationallicence Acromegaly nationallicence Cushing's disease nationallicence Immunohistochemistry nationallicence Electron microscopy nationallicence Magnetic resonance nationallicence Transsphenoidal surgery nationallicence Zieliński Grzegorz Department of Neurosurgery, Military Institute of Medicine, 128 Szaserów Street., 04-141 Warszawa 44, Warsaw, Poland aut Maksymowicz Maria Department of Pathology, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland aut Podgórski Jan Department of Neurosurgery, Military Institute of Medicine, 128 Szaserów Street., 04-141 Warszawa 44, Warsaw, Poland aut Olszewski Włodzimierz Department of Pathology, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland aut Endocrine Pathology Springer US; http://www.springer-ny.com 24/2(2013-06-01), 92-99 1046-3976 24:2<92 2013 24 12022 https://doi.org/10.1007/s12022-013-9237-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12022-013-9237-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zieliński Grzegorz Department of Neurosurgery, Military Institute of Medicine, 128 Szaserów Street., 04-141 Warszawa 44, Warsaw, Poland aut NATIONALLICENCE 700 1- Maksymowicz Maria Department of Pathology, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland aut NATIONALLICENCE 700 1- Podgórski Jan Department of Neurosurgery, Military Institute of Medicine, 128 Szaserów Street., 04-141 Warszawa 44, Warsaw, Poland aut NATIONALLICENCE 700 1- Olszewski Włodzimierz Department of Pathology, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland aut NATIONALLICENCE 773 0- Endocrine Pathology Springer US; http://www.springer-ny.com 24/2(2013-06-01), 92-99 1046-3976 24:2<92 2013 24 12022 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer