naa a22 4500 51077363X CHVBK 20180411083223.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12022-013-9245-z doi (NATIONALLICENCE)springer-10.1007/s12022-013-9245-z Clinical Utility of KAP-1 Expression in Thyroid Lesions [Elektronische Daten] [Mariana Martins, Marjory Marcello, Elaine Morari, Lucas Cunha, Fernando Soares, José Vassallo, Laura Ward] Although there are evidences of the involvement of KAP-1 in other tumors, data on differentiated thyroid carcinomas (DTC) are still lacking. We aimed to evaluate KAP-1 clinical utility in the diagnosis and prognosis of DTC. We used both visual immunohistochemistry and a semiquantitative analysis to evaluate KAP-1 expression in 230 thyroid carcinomas and 131 noncancerous thyroid nodules. There were 43 follicular carcinomas (FC) and 187 papillary thyroid carcinomas (PTC), including 130 classic (CPTC), 4 tall cells (TCPTC), and 53 follicular variants (FVPTC). Patients were followed up for 53.8 ± 41months. They were classified as free-of-disease (142 cases) or poor outcome (25 cases—10 deaths), according to their serum Tg levels and image evidences. KAP-1 was identified in 78% PTC, 75% TCPTC, 74% FC, 72% FVPTC, 55% FA, 44% hyperplasia, and 11% normal thyroid tissues. A ROC analysis identified malignant nodules with 69% sensitivity and 75% specificity, using a cutoff of 73.19. In addition to distinguishing benign from malignant thyroid tissues (p < 0.0001), KAP-1 expression differentiated CPTC from nodular hyperplasia (p < 0.0001), CPTC from FA (p = 0.0028), FVPTC from hyperplasia (p = 0.0039), and FC from hyperplasia (p = 0.0025). Furthermore, KAP-1 was more expressed in larger tumors (>4cm; p = 0.0038) and in individuals who presented recurrences/metastases (p = 0.0130). We suggest that KAP-1 may help diagnose thyroid nodules, characterize follicular-patterned thyroid lesions, and identify individuals with poor prognosis. Springer Science+Business Media New York, 2013 KAP-1 nationallicence Thyroid nodule nationallicence Follicular thyroid lesions nationallicence Outcome nationallicence Martins Mariana Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), University of Campinas (Unicamp), 126, Tessalia Vieira de Camargo St., Barão Geraldo, 13083-970, Campinas, São Paulo, Brazil aut Marcello Marjory Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), University of Campinas (Unicamp), 126, Tessalia Vieira de Camargo St., Barão Geraldo, 13083-970, Campinas, São Paulo, Brazil aut Morari Elaine Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), University of Campinas (Unicamp), 126, Tessalia Vieira de Camargo St., Barão Geraldo, 13083-970, Campinas, São Paulo, Brazil aut Cunha Lucas Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), University of Campinas (Unicamp), 126, Tessalia Vieira de Camargo St., Barão Geraldo, 13083-970, Campinas, São Paulo, Brazil aut Soares Fernando Department of Pathology, Hospital AC Camargo—Antonio Prudente Foundation, 211, Professor Antonio Prudente St, São Paulo, São Paulo, Brazil aut Vassallo José Laboratory Investigative and Molecular Pathology (Ciped), Faculty of Medical Sciences (FCM), University of Campinas (Unicamp), 126, Tessália Vieira de Camargo St, Campinas, São Paulo, Brazil aut Ward Laura Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), University of Campinas (Unicamp), 126, Tessalia Vieira de Camargo St., Barão Geraldo, 13083-970, Campinas, São Paulo, Brazil aut Endocrine Pathology Springer US; http://www.springer-ny.com 24/2(2013-06-01), 77-82 1046-3976 24:2<77 2013 24 12022 https://doi.org/10.1007/s12022-013-9245-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12022-013-9245-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Martins Mariana Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), University of Campinas (Unicamp), 126, Tessalia Vieira de Camargo St., Barão Geraldo, 13083-970, Campinas, São Paulo, Brazil aut NATIONALLICENCE 700 1- Marcello Marjory Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), University of Campinas (Unicamp), 126, Tessalia Vieira de Camargo St., Barão Geraldo, 13083-970, Campinas, São Paulo, Brazil aut NATIONALLICENCE 700 1- Morari Elaine Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), University of Campinas (Unicamp), 126, Tessalia Vieira de Camargo St., Barão Geraldo, 13083-970, Campinas, São Paulo, Brazil aut NATIONALLICENCE 700 1- Cunha Lucas Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), University of Campinas (Unicamp), 126, Tessalia Vieira de Camargo St., Barão Geraldo, 13083-970, Campinas, São Paulo, Brazil aut NATIONALLICENCE 700 1- Soares Fernando Department of Pathology, Hospital AC Camargo—Antonio Prudente Foundation, 211, Professor Antonio Prudente St, São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Vassallo José Laboratory Investigative and Molecular Pathology (Ciped), Faculty of Medical Sciences (FCM), University of Campinas (Unicamp), 126, Tessália Vieira de Camargo St, Campinas, São Paulo, Brazil aut NATIONALLICENCE 700 1- Ward Laura Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), University of Campinas (Unicamp), 126, Tessalia Vieira de Camargo St., Barão Geraldo, 13083-970, Campinas, São Paulo, Brazil aut NATIONALLICENCE 773 0- Endocrine Pathology Springer US; http://www.springer-ny.com 24/2(2013-06-01), 77-82 1046-3976 24:2<77 2013 24 12022 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer