naa a22 4500 510774571 CHVBK 20180411083226.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s12210-012-0220-2 doi (NATIONALLICENCE)springer-10.1007/s12210-012-0220-2 Blaser Hans-Ulrich Furglerstrasse 10, 9000, St. Gallen, Switzerland aut Chirality and its implications for the pharmaceutical industry [Elektronische Daten] [Hans-Ulrich Blaser] After a short introduction to the general phenomenon of chirality, the implications for synthesis and application of chiral drugs are discussed. In a first part, the historical development is briefly described. Up to the 1950s, most medications were either of natural origin, or made semi-synthetically from natural products. In these cases, only one enantiomer was usually present, i.e., the drugs were used as single enantiomers. This changed when totally synthetic drugs began to dominate the market, since these drugs were usually prepared, tested and applied as racemates. Due to the observation of negative effects such as the Thalidomide (Contergan) tragedy, stricter regulations were introduced and as a consequence, chiral drugs are now almost exclusively applied as single enantiomers. In a second part, the challenges for the industrial synthesis of chiral drugs are discussed. The various approaches to prepare enantiomerically pure compounds are briefly described and discussed in the context of industrial process development. Important for the choice of the production technology are criteria such as time constraint, complexity of the molecule, cost considerations and maturity of the technology. Accademia Nazionale dei Lincei, 2013 Chiral drugs nationallicence Enantioselective synthesis nationallicence Industrial synthesis nationallicence Process development nationallicence Resolution of racemates nationallicence Rendiconti Lincei Springer Milan 24/3(2013-09-01), 213-216 2037-4631 24:3<213 2013 24 12210 https://doi.org/10.1007/s12210-012-0220-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12210-012-0220-2 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Blaser Hans-Ulrich Furglerstrasse 10, 9000, St. Gallen, Switzerland aut NATIONALLICENCE 773 0- Rendiconti Lincei Springer Milan 24/3(2013-09-01), 213-216 2037-4631 24:3<213 2013 24 12210 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer