naa a22 4500 510775659 CHVBK 20180411083229.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s12975-012-0243-0 doi (NATIONALLICENCE)springer-10.1007/s12975-012-0243-0 Zhao Heng Department of Neurosurgery, Stanford University School of Medicine, MSLS Bldg., Room P306, 1201 Welch Rd., Room P306, 94305-5327, Stanford, CA, USA aut Hurdles to Clear Before Clinical Translation of Ischemic Postconditioning Against Stroke [Elektronische Daten] [Heng Zhao] Ischemic postconditioning has been established for its protective effects against stroke in animal models. It is performed after post-stroke reperfusion and refers to a series of induced ischemia or a single brief one. This review article addresses major hurdles in clinical translation of ischemic postconditioning to stroke patients, including potential hazards, the lack of well-defined protective paradigms, and the paucity of deeply understood protective mechanisms. A hormetic model, often used in toxicology to describe a dose-dependent response to a toxic agent, is suggested to study both beneficial and detrimental effects of ischemic postconditioning. Experimental strategies are discussed, including how to define the hazards of ischemic (homologous) postconditioning and the possibility of employing non-ischemic (heterologous) postconditioning to facilitate clinical translation. This review concludes that a more detailed assessment of ischemic postconditioning and studies of a broad range of heterologous postconditioning models are warranted for future clinical translation. Springer Science+Business Media New York, 2013 Ischemic postconditioning nationallicence Preconditioning nationallicence Stroke nationallicence Hormesis nationallicence Clinical translation nationallicence Translational Stroke Research Springer US; http://www.springer-ny.com 4/1(2013-02-01), 63-70 1868-4483 4:1<63 2013 4 12975 https://doi.org/10.1007/s12975-012-0243-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12975-012-0243-0 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Zhao Heng Department of Neurosurgery, Stanford University School of Medicine, MSLS Bldg., Room P306, 1201 Welch Rd., Room P306, 94305-5327, Stanford, CA, USA aut NATIONALLICENCE 773 0- Translational Stroke Research Springer US; http://www.springer-ny.com 4/1(2013-02-01), 63-70 1868-4483 4:1<63 2013 4 12975 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer