naa a22 4500 510775675 CHVBK 20180411083229.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s12975-012-0220-7 doi (NATIONALLICENCE)springer-10.1007/s12975-012-0220-7 Koch Sebastian School of Medicine, University of Miami, 1150 NW 14th Street, 33136, Miami, FL, USA aut Moving Towards Preconditioning for Neurological Disorders: Are We Ready for Clinical Trials? [Elektronische Daten] [Sebastian Koch] The large volume of preclinical investigations begets the question of whether to proceed with clinical trials in preconditioning for neurological disorders, particularly for treatment of human cerebral ischemia. This important question was discussed during the 2nd Translational Preconditioning Meeting held at the University of Miami. While recommendations for proceeding to clinical trials have been devised in other fields of stroke therapy, such as neuroprotection, no such guidelines exist for preconditioning. During the discussion, the general opinion was to proceed with clinical preconditioning trials, with the understanding that initial trials be exploratory in nature and focus on the development of biomarkers, assessing the elicitability of the preconditioning response. Springer Science+Business Media New York, 2012 Remote ischemic preconditioning nationallicence Clinical trials nationallicence Exploratory investigations nationallicence Translational Stroke Research Springer US; http://www.springer-ny.com 4/1(2013-02-01), 15-18 1868-4483 4:1<15 2013 4 12975 https://doi.org/10.1007/s12975-012-0220-7 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12975-012-0220-7 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Koch Sebastian School of Medicine, University of Miami, 1150 NW 14th Street, 33136, Miami, FL, USA aut NATIONALLICENCE 773 0- Translational Stroke Research Springer US; http://www.springer-ny.com 4/1(2013-02-01), 15-18 1868-4483 4:1<15 2013 4 12975 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer