naa a22 4500 510775683 CHVBK 20180411083229.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s12975-012-0235-0 doi (NATIONALLICENCE)springer-10.1007/s12975-012-0235-0 Epigenetics and the Environment: In Search of the "Toleroasome” Vital to Execution of Ischemic Preconditioning [Elektronische Daten] [David Brand, Rajiv Ratan] Activation and repression of gene expression are key features of ischemic tolerance. Converging lines of inquiry from several groups suggests that epigenetic proteins may transduce sublethal stresses, including bioenergetic or oxidative stress into durable (2-3days) changes in gene expression that mediate ischemic tolerance. Here we discuss the potential mechanisms by which changes in cell state (e.g., ATP, NAD+, and oxygen) can modify specific targets including polycomb complexes, jumonji domain histone demethylases, and zinc and NAD-dependent histone decetylases and thus trigger an adaptive program. A major unanswered question is whether these proteins work in parallel or convergently as part of a "tolerosome” (tolero is the Latin word for tolerance), a multiprotein complex recruited to promoters or enhancers of specific genes, to mediate preconditioning. Whatever the case may be, epigenetic proteins are fertile targets for the treatment of stroke. Springer Science+Business Media New York, 2013 Epigenetics nationallicence Ischemic preconditioning nationallicence Histone demethylase nationallicence Histone deacetylase nationallicence Polycomb nationallicence Brand David Amherst College, Amherst, MA, USA aut Ratan Rajiv Burke-Cornell Medical Research Institute, 785 Mamaroneck Avenue, 10605, White Plains, NY, USA aut Translational Stroke Research Springer US; http://www.springer-ny.com 4/1(2013-02-01), 56-62 1868-4483 4:1<56 2013 4 12975 https://doi.org/10.1007/s12975-012-0235-0 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12975-012-0235-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brand David Amherst College, Amherst, MA, USA aut NATIONALLICENCE 700 1- Ratan Rajiv Burke-Cornell Medical Research Institute, 785 Mamaroneck Avenue, 10605, White Plains, NY, USA aut NATIONALLICENCE 773 0- Translational Stroke Research Springer US; http://www.springer-ny.com 4/1(2013-02-01), 56-62 1868-4483 4:1<56 2013 4 12975 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer