naa a22 4500 510775691 CHVBK 20180411083229.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s12975-012-0245-y doi (NATIONALLICENCE)springer-10.1007/s12975-012-0245-y Nrf2 to Pre-condition the Brain Against Injury Caused by Products of Hemolysis After ICH [Elektronische Daten] [Xiurong Zhao, Jaroslaw Aronowski] Brain damage caused by intracerebral hemorrhage is mediated in part by the toxicity of extravascular blood deposited in the brain parenchyma during the hematoma formation. In this paper, we discuss the therapeutic benefits and potential mechanisms associated with the activation of transcription factor Nrf2 regarding its role in defending the brain tissue against toxicity of the blood, a component of secondary injury. We emphasize the pleiotropic capacity of Nrf2 as it recruits multiple pathways aiming at reducing deleterious effects of blood lysis products. Springer Science+Business Media New York, 2013 Intracerebral hemorrhage nationallicence Nrf2 nationallicence Oxidative stress nationallicence Cytoprotection nationallicence Zhao Xiurong Stroke Program, Department of Neurology, University of Texas Medical School, 6431 Fannin, Suite 7.210, 77030, Houston, TX, USA aut Aronowski Jaroslaw Stroke Program, Department of Neurology, University of Texas Medical School, 6431 Fannin, Suite 7.210, 77030, Houston, TX, USA aut Translational Stroke Research Springer US; http://www.springer-ny.com 4/1(2013-02-01), 71-75 1868-4483 4:1<71 2013 4 12975 https://doi.org/10.1007/s12975-012-0245-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12975-012-0245-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhao Xiurong Stroke Program, Department of Neurology, University of Texas Medical School, 6431 Fannin, Suite 7.210, 77030, Houston, TX, USA aut NATIONALLICENCE 700 1- Aronowski Jaroslaw Stroke Program, Department of Neurology, University of Texas Medical School, 6431 Fannin, Suite 7.210, 77030, Houston, TX, USA aut NATIONALLICENCE 773 0- Translational Stroke Research Springer US; http://www.springer-ny.com 4/1(2013-02-01), 71-75 1868-4483 4:1<71 2013 4 12975 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer