naa a22 4500 510775713 CHVBK 20180411083229.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s12975-012-0219-0 doi (NATIONALLICENCE)springer-10.1007/s12975-012-0219-0 Should the STAIR Criteria Be Modified for Preconditioning Studies? [Elektronische Daten] [Michael Wang, Guohua Xi, Richard Keep] Diverse preconditioning (PC) stimuli protect against a wide variety of neuronal insults in animal models, engendering enthusiasm that PC could be used to protect the brain clinically. Candidate clinical applications include cardiac and vascular surgery, after subarachnoid hemorrhage, and prior to conditions in which acute neuronal injury is anticipated. However, disappointments in clinical validation of multiple neuroprotectants suggest potential problems translating animal data into successful human therapies. Thus, despite strong promise of preclinical PC studies, caution should be maintained in translating these findings into clinical applications. The Stroke Therapy Academic Industry Roundtable working group and the National institute of Neurological Diseases and Stroke proposed working guidelines to improve the utility of preclinical studies that form the foundation of therapies for neurological disease. Here, we review the applicability of these consensus criteria to preconditioning studies and discuss additional considerations for PC studies. We propose that special attention should be paid to several areas, including (1) safety and dosage of PC treatments, (2) meticulously matching preclinical modeling to the human condition to be tested, and (3) timing of both the initiation and discontinuation of the PC stimulus relative to injury ictus. Springer Science+Business Media New York (outside the USA), 2012 Translational research nationallicence Preconditioning nationallicence Ischemic tolerance nationallicence STAIR nationallicence Remote ischemic preconditioning nationallicence Wang Michael Department of Neurology, University of Michigan, 7629 Med Sci II, 1137 Catherine Street, Box 5622, 48109-5622, Ann Arbor, MI, USA aut Xi Guohua Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA aut Keep Richard Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA aut Translational Stroke Research Springer US; http://www.springer-ny.com 4/1(2013-02-01), 3-14 1868-4483 4:1<3 2013 4 12975 https://doi.org/10.1007/s12975-012-0219-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12975-012-0219-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Michael Department of Neurology, University of Michigan, 7629 Med Sci II, 1137 Catherine Street, Box 5622, 48109-5622, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Xi Guohua Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Keep Richard Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA aut NATIONALLICENCE 773 0- Translational Stroke Research Springer US; http://www.springer-ny.com 4/1(2013-02-01), 3-14 1868-4483 4:1<3 2013 4 12975 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer