naa a22 4500 51077573X CHVBK 20180411083229.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s12975-012-0251-0 doi (NATIONALLICENCE)springer-10.1007/s12975-012-0251-0 Preconditioning Strategy in Stem Cell Transplantation Therapy [Elektronische Daten] [Shan Yu, Zheng Wei, Ling Wei] Stem cell transplantation therapy has emerged as a promising regenerative medicine for ischemic stroke and other neurodegenerative disorders. However, many issues and problems remain to be resolved before successful clinical applications of cell-based therapy. To this end, some recent investigations have sought to benefit from well-known mechanisms of ischemic/hypoxic preconditioning. Ischemic/hypoxic preconditioning activates endogenous defense mechanisms that show marked protective effects against multiple insults found in ischemic stroke and other acute attacks. As in many other cell types, a sublethal hypoxic exposure significantly increases the tolerance and regenerative properties of stem cells and progenitor cells. So far, a variety of preconditioning triggers have been tested on different stem cells and progenitor cells. Preconditioned stem cells and progenitors generally show much better cell survival, increased neuronal differentiation, enhanced paracrine effects leading to increased trophic support, and improved homing to the lesion site. Transplantation of preconditioned cells helps to suppress inflammatory factors and immune responses, and promote functional recovery. Although the preconditioning strategy in stem cell therapy is still an emerging research area, accumulating information from reports over the last few years already indicates it as an attractive, if not essential, prerequisite for transplanted cells. It is expected that stem cell preconditioning and its clinical applications will attract more attention in both the basic research field of preconditioning as well as in the field of stem cell translational research. This review summarizes the most important findings in this active research area, covering the preconditioning triggers, potential mechanisms, mediators, and functional benefits for stem cell transplant therapy. Springer Science+Business Media New York, 2013 Stem cell preconditioning nationallicence Stroke nationallicence Ischemia nationallicence Neurodegenerative disorder nationallicence Heart attack nationallicence BDNF : Brain-derived neurotrophic factor nationallicence CoPP : Cobalt protoporphyrin nationallicence Cx43 : Connexin-43 nationallicence CXCR : CXC chemokine receptor nationallicence EPO : Erythropoietin nationallicence ERK : Extracellular signal-regulated kinase nationallicence FAK : Focal adhesion kinase nationallicence GSK-3β : Glycogen synthase kinase-3β nationallicence HIF-1 : Hypoxia-inducible factor-1 nationallicence HSPs : Heat shock protein nationallicence IGF-1 : Insulin-like growth factor-1 nationallicence IL-1β : Interleukin-1beta nationallicence IL-6 : Interleukin-6 nationallicence LPS : Lipopolysaccharide nationallicence miR : micro-RNA nationallicence MMP : Matrix metalloproteinase nationallicence NOS : Nitric oxide synthase nationallicence polyP : Polyphosphate nationallicence PTP : Permeability transition pore nationallicence ROS : Reactive oxygen species nationallicence SDF-1 : Stromal-derived factor-1 nationallicence TNF-α : Tumor necrosis factor alpha nationallicence VEGF : Vascular endothelial growth factor nationallicence Yu Shan Department of Anesthesiology, Emory University School of Medicine, 101 Woodruff Memorial Research Building, Suite 620, 30322, Atlanta, GA, USA aut Wei Zheng Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, 100191, Beijing, China aut Wei Ling Department of Anesthesiology, Emory University School of Medicine, 101 Woodruff Memorial Research Building, Suite 620, 30322, Atlanta, GA, USA aut Translational Stroke Research Springer US; http://www.springer-ny.com 4/1(2013-02-01), 76-88 1868-4483 4:1<76 2013 4 12975 https://doi.org/10.1007/s12975-012-0251-0 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12975-012-0251-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yu Shan Department of Anesthesiology, Emory University School of Medicine, 101 Woodruff Memorial Research Building, Suite 620, 30322, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Wei Zheng Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, 100191, Beijing, China aut NATIONALLICENCE 700 1- Wei Ling Department of Anesthesiology, Emory University School of Medicine, 101 Woodruff Memorial Research Building, Suite 620, 30322, Atlanta, GA, USA aut NATIONALLICENCE 773 0- Translational Stroke Research Springer US; http://www.springer-ny.com 4/1(2013-02-01), 76-88 1868-4483 4:1<76 2013 4 12975 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer