naa a22 4500 510775802 CHVBK 20180411083229.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s12975-013-0280-3 doi (NATIONALLICENCE)springer-10.1007/s12975-013-0280-3 MicroRNAs Regulate the Chaperone Network in Cerebral Ischemia [Elektronische Daten] [Yi-Bing Ouyang, Rona Giffard] The highly evolutionarily conserved 70kDa heat shock protein (HSP70) family was first understood for its role in protein folding and response to stress. Subsequently, additional functions have been identified for it in regulation of organelle interaction, of the inflammatory response, and of cell death and survival. Overexpression of HSP70 family members is associated with increased resistance to and improved recovery from cerebral ischemia. MicroRNAs (miRNAs) are important posttranscriptional regulators that interact with multiple target messenger RNAs (mRNA) coordinately regulating target genes, including chaperones. The members of the HSP70 family are now appreciated to work together as networks to facilitate organelle communication and regulate inflammatory signaling and cell survival after cerebral ischemia. This review will focus on the new concept of the role of the chaperone network in the organelle network and its novel regulation by miRNA. Springer Science+Business Media New York, 2013 Chaperone nationallicence Mitochondria nationallicence Endoplasmic reticulum nationallicence MicroRNA nationallicence Stroke nationallicence Ouyang Yi-Bing Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, S272A and S290, 94305-5117, Stanford, CA, USA aut Giffard Rona Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, S272A and S290, 94305-5117, Stanford, CA, USA aut Translational Stroke Research Springer US; http://www.springer-ny.com 4/6(2013-12-01), 693-703 1868-4483 4:6<693 2013 4 12975 https://doi.org/10.1007/s12975-013-0280-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12975-013-0280-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ouyang Yi-Bing Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, S272A and S290, 94305-5117, Stanford, CA, USA aut NATIONALLICENCE 700 1- Giffard Rona Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, S272A and S290, 94305-5117, Stanford, CA, USA aut NATIONALLICENCE 773 0- Translational Stroke Research Springer US; http://www.springer-ny.com 4/6(2013-12-01), 693-703 1868-4483 4:6<693 2013 4 12975 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer