naa a22 4500 510775829 CHVBK 20180411083230.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s12975-013-0277-y doi (NATIONALLICENCE)springer-10.1007/s12975-013-0277-y SIRT1 Regulation Modulates Stroke Outcome [Elektronische Daten] [Valérie Petegnief, Anna Planas] Silent information regulator 1 (SIRT1) is a NAD+−dependent histone deacetylase that represses gene expression and plays a role in longevity. SIRT1 responds to diverse stress conditions and regulates metabolism in nutrient deficiency conditions; therefore, it is involved in adaptive pathways to better fulfill tissue needs in a disturbed environment. SIRT1 overexpression or activation is protective in neurodegenerative diseases. Its role in acute nervous system injury, such as brain ischemia, is emerging, but whether SIRT1 activation improves stroke outcome is still a matter of controversy. In the present review, we will document present knowledge about the contribution of SIRT1 in death/survival in cell and animal models of brain ischemia and discuss whether SIRT1 could be a valuable target for therapeutic intervention in human stroke. Springer Science+Business Media New York, 2013 Sirtuin nationallicence Histone deacetylase nationallicence Endogenous neuroprotection nationallicence Stress protein nationallicence Cerebral ischemia nationallicence Petegnief Valérie Department of Brain Ischemia and Neurodegeneration, Institute for Biomedical Research of Barcelona, Spanish Research Council, Institut d'Investigacions Biomèdiques August Pi Sunyer, Barcelona, Spain aut Planas Anna Department of Brain Ischemia and Neurodegeneration, Institute for Biomedical Research of Barcelona, Spanish Research Council, Institut d'Investigacions Biomèdiques August Pi Sunyer, Barcelona, Spain aut Translational Stroke Research Springer US; http://www.springer-ny.com 4/6(2013-12-01), 663-671 1868-4483 4:6<663 2013 4 12975 https://doi.org/10.1007/s12975-013-0277-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12975-013-0277-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Petegnief Valérie Department of Brain Ischemia and Neurodegeneration, Institute for Biomedical Research of Barcelona, Spanish Research Council, Institut d'Investigacions Biomèdiques August Pi Sunyer, Barcelona, Spain aut NATIONALLICENCE 700 1- Planas Anna Department of Brain Ischemia and Neurodegeneration, Institute for Biomedical Research of Barcelona, Spanish Research Council, Institut d'Investigacions Biomèdiques August Pi Sunyer, Barcelona, Spain aut NATIONALLICENCE 773 0- Translational Stroke Research Springer US; http://www.springer-ny.com 4/6(2013-12-01), 663-671 1868-4483 4:6<663 2013 4 12975 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer