naa a22 4500 510775837 CHVBK 20180411083230.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s12975-013-0269-y doi (NATIONALLICENCE)springer-10.1007/s12975-013-0269-y Pseudo-Continuous Arterial Spin Labelling MRI for Non-Invasive, Whole-Brain, Serial Quantification of Cerebral Blood Flow Following Aneurysmal Subarachnoid Haemorrhage [Elektronische Daten] [Michael Kelly, Matthew Rowland, Thomas Okell, Michael Chappell, Rufus Corkill, Richard Kerr, Jon Westbrook, Peter Jezzard, Kyle Pattinson] Delayed cerebral ischaemia (DCI) is the major cause of mortality and morbidity following aneurysmal subarachnoid haemorrhage (SAH). Recent experimental evidence from animal models has highlighted the need for non-invasive and robust measurements of brain tissue perfusion in patients in order to help understand the pathophysiology underlying DCI. Quantitative, serial, whole-brain cerebral perfusion measurements were obtained with pseudo-continuous arterial spin labelling (PCASL) magnetic resonance imaging (MRI) in six SAH patients acutely following endovascular coiling. This technique requires no injected contrast or radioactive isotopes. MRI scanning was well tolerated. Artefact from endovascular coils was minimal. PCASL MRI was able to detect time-dependent and patient-specific changes in voxel-wise and regional cerebral blood flow. These changes reflected changes in clinical condition. Data obtained in healthy controls using the same experimental protocol confirm the reliability and reproducibility of these results. This is the first study to use whole-brain, quantitative PCASL to identify time-dependent changes in cerebral blood flow at the tissue level in the acute period following SAH. This technique has the potential to better understand changes in cerebral pathophysiology as a consequence of aneurysm rupture. Springer Science+Business Media New York, 2013 Aneurysmal subarachnoid haemorrhage nationallicence Delayed cerebral ischaemia nationallicence Arterial spin labelling nationallicence Magnetic resonance imaging nationallicence Kelly Michael Nuffield Department of Clinical Neurosciences and Oxford Acute Vascular Imaging Centre, University of Oxford, John Radcliffe Hospital, OX3 9DU, Oxford, UK aut Rowland Matthew Nuffield Department of Clinical Neurosciences and Oxford Acute Vascular Imaging Centre, University of Oxford, John Radcliffe Hospital, OX3 9DU, Oxford, UK aut Okell Thomas Nuffield Department of Clinical Neurosciences and Oxford Acute Vascular Imaging Centre, University of Oxford, John Radcliffe Hospital, OX3 9DU, Oxford, UK aut Chappell Michael Institute of Biomedical Engineering, University of Oxford, OX3 7DQ, Oxford, UK aut Corkill Rufus Neurointensive Care, Oxford University Hospitals, NHS Trust, OX3 9DU, Oxford, UK aut Kerr Richard Neurointensive Care, Oxford University Hospitals, NHS Trust, OX3 9DU, Oxford, UK aut Westbrook Jon Nuffield Department of Clinical Neurosciences and Oxford Acute Vascular Imaging Centre, University of Oxford, John Radcliffe Hospital, OX3 9DU, Oxford, UK aut Jezzard Peter Nuffield Department of Clinical Neurosciences and Oxford Acute Vascular Imaging Centre, University of Oxford, John Radcliffe Hospital, OX3 9DU, Oxford, UK aut Pattinson Kyle Nuffield Department of Clinical Neurosciences and Oxford Acute Vascular Imaging Centre, University of Oxford, John Radcliffe Hospital, OX3 9DU, Oxford, UK aut Translational Stroke Research Springer US; http://www.springer-ny.com 4/6(2013-12-01), 710-718 1868-4483 4:6<710 2013 4 12975 https://doi.org/10.1007/s12975-013-0269-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12975-013-0269-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kelly Michael Nuffield Department of Clinical Neurosciences and Oxford Acute Vascular Imaging Centre, University of Oxford, John Radcliffe Hospital, OX3 9DU, Oxford, UK aut NATIONALLICENCE 700 1- Rowland Matthew Nuffield Department of Clinical Neurosciences and Oxford Acute Vascular Imaging Centre, University of Oxford, John Radcliffe Hospital, OX3 9DU, Oxford, UK aut NATIONALLICENCE 700 1- Okell Thomas Nuffield Department of Clinical Neurosciences and Oxford Acute Vascular Imaging Centre, University of Oxford, John Radcliffe Hospital, OX3 9DU, Oxford, UK aut NATIONALLICENCE 700 1- Chappell Michael Institute of Biomedical Engineering, University of Oxford, OX3 7DQ, Oxford, UK aut NATIONALLICENCE 700 1- Corkill Rufus Neurointensive Care, Oxford University Hospitals, NHS Trust, OX3 9DU, Oxford, UK aut NATIONALLICENCE 700 1- Kerr Richard Neurointensive Care, Oxford University Hospitals, NHS Trust, OX3 9DU, Oxford, UK aut NATIONALLICENCE 700 1- Westbrook Jon Nuffield Department of Clinical Neurosciences and Oxford Acute Vascular Imaging Centre, University of Oxford, John Radcliffe Hospital, OX3 9DU, Oxford, UK aut NATIONALLICENCE 700 1- Jezzard Peter Nuffield Department of Clinical Neurosciences and Oxford Acute Vascular Imaging Centre, University of Oxford, John Radcliffe Hospital, OX3 9DU, Oxford, UK aut NATIONALLICENCE 700 1- Pattinson Kyle Nuffield Department of Clinical Neurosciences and Oxford Acute Vascular Imaging Centre, University of Oxford, John Radcliffe Hospital, OX3 9DU, Oxford, UK aut NATIONALLICENCE 773 0- Translational Stroke Research Springer US; http://www.springer-ny.com 4/6(2013-12-01), 710-718 1868-4483 4:6<710 2013 4 12975 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer