naa a22 4500 510775888 CHVBK 20180411083230.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s12975-013-0299-5 doi (NATIONALLICENCE)springer-10.1007/s12975-013-0299-5 Protein Misfolding, Aggregation, and Autophagy After Brain Ischemia [Elektronische Daten] [Tianfei Luo, Yujung Park, Xin Sun, Chunli Liu, Bingren Hu] Ischemic brain injury is a common disorder linked to a variety of diseases. Significant progress has been made in our understanding of the underlying mechanisms. Previous studies show that protein misfolding, aggregation, and multiple organelle damage are major pathological events in postischemic neurons. The autophagy pathway is the chief route for bulk degradation of protein aggregates and damaged organelles. The latest studies suggest that impairment of autophagy contributes to abnormal protein aggregation and organelle damages after brain ischemia. This article reviews recent studies of protein misfolding, aggregation, and impairment of autophagy after brain ischemia. Springer Science+Business Media New York, 2013 Brain ischemia nationallicence Protein misfolding nationallicence Protein aggregation nationallicence Autophagy nationallicence Protein synthesis nationallicence Chaperone nationallicence Multiple organelle damage nationallicence Ubiquitin-proteasomal system nationallicence AP : Autophagosome nationallicence AL : Autolysosome nationallicence 2VO : Two-vessel occlusion with hypotension ischemia model nationallicence HSC70 : Heat-shock cognate protein 70 nationallicence HSP40 : Heat-shock protein 40 nationallicence ATG : Autophagic gene-related protein nationallicence LC3 : Microtubule-associated protein light chain 3 nationallicence DG : Dentate gyrus nationallicence ER : Endoplasmic reticulum nationallicence Luo Tianfei Shock, Trauma and Anesthesiology Research Center, Department of Anesthesiology, University of Maryland School of Medicine, 21201, Baltimore, MD, USA aut Park Yujung Shock, Trauma and Anesthesiology Research Center, Department of Anesthesiology, University of Maryland School of Medicine, 21201, Baltimore, MD, USA aut Sun Xin Shock, Trauma and Anesthesiology Research Center, Department of Anesthesiology, University of Maryland School of Medicine, 21201, Baltimore, MD, USA aut Liu Chunli Shock, Trauma and Anesthesiology Research Center, Department of Anesthesiology, University of Maryland School of Medicine, 21201, Baltimore, MD, USA aut Hu Bingren Shock, Trauma and Anesthesiology Research Center, Department of Anesthesiology, University of Maryland School of Medicine, 21201, Baltimore, MD, USA aut Translational Stroke Research Springer US; http://www.springer-ny.com 4/6(2013-12-01), 581-588 1868-4483 4:6<581 2013 4 12975 https://doi.org/10.1007/s12975-013-0299-5 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12975-013-0299-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Luo Tianfei Shock, Trauma and Anesthesiology Research Center, Department of Anesthesiology, University of Maryland School of Medicine, 21201, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Park Yujung Shock, Trauma and Anesthesiology Research Center, Department of Anesthesiology, University of Maryland School of Medicine, 21201, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Sun Xin Shock, Trauma and Anesthesiology Research Center, Department of Anesthesiology, University of Maryland School of Medicine, 21201, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Liu Chunli Shock, Trauma and Anesthesiology Research Center, Department of Anesthesiology, University of Maryland School of Medicine, 21201, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Hu Bingren Shock, Trauma and Anesthesiology Research Center, Department of Anesthesiology, University of Maryland School of Medicine, 21201, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Translational Stroke Research Springer US; http://www.springer-ny.com 4/6(2013-12-01), 581-588 1868-4483 4:6<581 2013 4 12975 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer