naa a22 4500 510775950 CHVBK 20180411083230.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12975-012-0209-2 doi (NATIONALLICENCE)springer-10.1007/s12975-012-0209-2 RIGOR Guidelines: Escalating STAIR and STEPS for Effective Translational Research [Elektronische Daten] [Paul Lapchak, John Zhang, Linda Noble-Haeusslein] Stroke continues to be a serious and significant health problem in the USA and worldwide. This article will emphasize the need for good laboratory practices, transparent scientific reporting, and the use of translational research models representative of the disease state to develop effective treatments. This will allow for the testing and development of new innovative strategies so that efficacious therapies can be developed to treat ischemic and hemorrhagic stroke. This article recommends guidelines for effective translational research, most importantly, the need for study blinding, study group randomization, power analysis, accurate statistical analysis, and a conflict of interest statement. Additional guidelines to ensure reproducibility of results and confirmation of efficacy in multiple species are discussed. The Author(s), 2012 Translational nationallicence Brain nationallicence Stroke nationallicence Hemorrhage nationallicence SAH nationallicence ICH nationallicence Clinical Trial nationallicence NIHSS nationallicence STAIR nationallicence STEPS nationallicence RIGOR nationallicence Lapchak Paul Department of Neurology, Cedars-Sinai Medical Center, Davis Research Building, D-2091, 110N. George Burns Road, 90048, Los Angeles, CA, USA aut Zhang John Department of Neurosurgery, Anesthesiology, Neurology, and Physiology and Pharmacology, Loma Linda University School of Medicine, 92350, Loma Linda, CA, USA aut Noble-Haeusslein Linda Department of Neurological Surgery, Physical Therapy and Rehabilitation Science, and Brain and Spinal Injury Center (BASIC), University of California, San Francisco, Box 0112, 513 Parnassus Avenue, HSE-722, 94143-0112, San Francisco, CA, USA aut Translational Stroke Research Springer-Verlag 4/3(2013-06-01), 279-285 1868-4483 4:3<279 2013 4 12975 https://doi.org/10.1007/s12975-012-0209-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12975-012-0209-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lapchak Paul Department of Neurology, Cedars-Sinai Medical Center, Davis Research Building, D-2091, 110N. George Burns Road, 90048, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Zhang John Department of Neurosurgery, Anesthesiology, Neurology, and Physiology and Pharmacology, Loma Linda University School of Medicine, 92350, Loma Linda, CA, USA aut NATIONALLICENCE 700 1- Noble-Haeusslein Linda Department of Neurological Surgery, Physical Therapy and Rehabilitation Science, and Brain and Spinal Injury Center (BASIC), University of California, San Francisco, Box 0112, 513 Parnassus Avenue, HSE-722, 94143-0112, San Francisco, CA, USA aut NATIONALLICENCE 773 0- Translational Stroke Research Springer-Verlag 4/3(2013-06-01), 279-285 1868-4483 4:3<279 2013 4 12975 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer