naa a22 4500 510776000 CHVBK 20180411083230.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12975-012-0241-2 doi (NATIONALLICENCE)springer-10.1007/s12975-012-0241-2 In Vivo Animal Stroke Models [Elektronische Daten] A Rationale for Rodent and Non-Human Primate Models [Naoki Tajiri, Travis Dailey, Christopher Metcalf, Yusef Mosley, Tsz Lau, Meaghan Staples, Harry van Loveren, Seung Kim, Tetsumori Yamashima, Takao Yasuhara, Isao Date, Yuji Kaneko, Cesario Borlongan] On average, every 4 min an individual dies from a stroke, accounting for one out of every 18 deaths in the United States. Approximately 795,000 Americans have a new or recurrent stroke each year, with just over 600,000 of these being first attack Roger et al. (Circulation, 125(1): 188-197, 2012). There have been multiple animal models of stroke demonstrating that novel therapeutics can help improve the clinical outcome. However, these results have failed to show the same outcomes when tested in human clinical trials. This review will discuss the current in vivo animal models of stroke, advantages and limitations, and the rationale for employing these animal models to satisfy translational gating items for examination of neuroprotective, as well as neurorestorative strategies in stroke patients. An emphasis in the present discussion of therapeutics development is given to stem cell therapy for stroke. Springer Science+Business Media New York, 2013 Cerebral ischemia nationallicence Animals nationallicence Basic research nationallicence Translational nationallicence Clinical application nationallicence Tajiri Naoki Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 33612, Tampa, FL, USA aut Dailey Travis Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 33612, Tampa, FL, USA aut Metcalf Christopher Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 33612, Tampa, FL, USA aut Mosley Yusef Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 33612, Tampa, FL, USA aut Lau Tsz Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 33612, Tampa, FL, USA aut Staples Meaghan Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 33612, Tampa, FL, USA aut van Loveren Harry Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 33612, Tampa, FL, USA aut Kim Seung Department of Neurology, University of British Columbia, Vancouver, Canada aut Yamashima Tetsumori Department of Restorative Neurosurgery, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan aut Yasuhara Takao Department of Neurological Surgery, Okayama University Graduate School of Medicine, Okayama, Japan aut Date Isao Department of Neurological Surgery, Okayama University Graduate School of Medicine, Okayama, Japan aut Kaneko Yuji Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 33612, Tampa, FL, USA aut Borlongan Cesario Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 33612, Tampa, FL, USA aut Translational Stroke Research Springer-Verlag 4/3(2013-06-01), 308-321 1868-4483 4:3<308 2013 4 12975 https://doi.org/10.1007/s12975-012-0241-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12975-012-0241-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tajiri Naoki Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Dailey Travis Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Metcalf Christopher Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Mosley Yusef Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Lau Tsz Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Staples Meaghan Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- van Loveren Harry Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Kim Seung Department of Neurology, University of British Columbia, Vancouver, Canada aut NATIONALLICENCE 700 1- Yamashima Tetsumori Department of Restorative Neurosurgery, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan aut NATIONALLICENCE 700 1- Yasuhara Takao Department of Neurological Surgery, Okayama University Graduate School of Medicine, Okayama, Japan aut NATIONALLICENCE 700 1- Date Isao Department of Neurological Surgery, Okayama University Graduate School of Medicine, Okayama, Japan aut NATIONALLICENCE 700 1- Kaneko Yuji Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Borlongan Cesario Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 33612, Tampa, FL, USA aut NATIONALLICENCE 773 0- Translational Stroke Research Springer-Verlag 4/3(2013-06-01), 308-321 1868-4483 4:3<308 2013 4 12975 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer