naa a22 4500 510776043 CHVBK 20180411083230.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s12975-012-0227-0 doi (NATIONALLICENCE)springer-10.1007/s12975-012-0227-0 Mechanism of the Sex Difference in Endothelial Dysfunction after Stroke [Elektronische Daten] [Catherine Davis, Stacy Fairbanks, Nabil Alkayed] Stroke, the number four cause of death in the USA, is a greatly debilitating event resulting from insufficient blood supply to the brain (cerebral ischemia). Endothelial dysfunction, primarily characterized by dampened endothelial-dependent vasodilation, is a major contributor to the development and outcome of stroke. This review discusses the role of soluble epoxide hydrolase, an enzyme responsible for the degradation of vasoprotective epoxyeicosatrienoic acids, in the context of the cerebral vasculature and its contribution to the sexual dimorphic nature of stroke. Springer Science+Business Media New York, 2012 sEH nationallicence Ischemia nationallicence Endothelia nationallicence EET nationallicence Brain nationallicence Sexual dimorphism nationallicence Davis Catherine Cerebrovascular Research Division, Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, 97239-3098, Portland, OR, USA aut Fairbanks Stacy Cerebrovascular Research Division, Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, 97239-3098, Portland, OR, USA aut Alkayed Nabil Cerebrovascular Research Division, Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, 97239-3098, Portland, OR, USA aut Translational Stroke Research Springer US; http://www.springer-ny.com 4/4(2013-08-01), 381-389 1868-4483 4:4<381 2013 4 12975 https://doi.org/10.1007/s12975-012-0227-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12975-012-0227-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Davis Catherine Cerebrovascular Research Division, Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, 97239-3098, Portland, OR, USA aut NATIONALLICENCE 700 1- Fairbanks Stacy Cerebrovascular Research Division, Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, 97239-3098, Portland, OR, USA aut NATIONALLICENCE 700 1- Alkayed Nabil Cerebrovascular Research Division, Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, 97239-3098, Portland, OR, USA aut NATIONALLICENCE 773 0- Translational Stroke Research Springer US; http://www.springer-ny.com 4/4(2013-08-01), 381-389 1868-4483 4:4<381 2013 4 12975 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer