naa a22 4500 510776108 CHVBK 20180411083230.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s12975-012-0230-5 doi (NATIONALLICENCE)springer-10.1007/s12975-012-0230-5 The Effects of Estrogen in Ischemic Stroke [Elektronische Daten] [Edward Koellhoffer, Louise McCullough] Stroke is a leading cause of death and the most common cause of long-term disability in the USA. Women have a lower incidence of stroke compared with men throughout most of the lifespan which has been ascribed to protective effects of gonadal steroids, most notably estrogen. Due to the lower stroke incidence observed in pre-menopausal women and robust preclinical evidence of neuroprotective and anti-inflammatory properties of estrogen, researchers have focused on the potential benefits of hormones to reduce ischemic brain injury. However, as women age, they are disproportionately affected by stroke, coincident with the loss of estrogen with menopause. The risk of stroke in elderly women exceeds that of men and it is clear that in some settings estrogen can have pro-inflammatory effects. This review will focus on estrogen and inflammation and its interaction with aging. Springer Science+Business Media New York, 2012 Stroke nationallicence Aging nationallicence Sex nationallicence Estrogen nationallicence Koellhoffer Edward Department of Neuroscience, University of Connecticut Health Center, 06030, Farmington, CT, USA aut McCullough Louise Department of Neuroscience, University of Connecticut Health Center, 06030, Farmington, CT, USA aut Translational Stroke Research Springer US; http://www.springer-ny.com 4/4(2013-08-01), 390-401 1868-4483 4:4<390 2013 4 12975 https://doi.org/10.1007/s12975-012-0230-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12975-012-0230-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koellhoffer Edward Department of Neuroscience, University of Connecticut Health Center, 06030, Farmington, CT, USA aut NATIONALLICENCE 700 1- McCullough Louise Department of Neuroscience, University of Connecticut Health Center, 06030, Farmington, CT, USA aut NATIONALLICENCE 773 0- Translational Stroke Research Springer US; http://www.springer-ny.com 4/4(2013-08-01), 390-401 1868-4483 4:4<390 2013 4 12975 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer