naa a22 4500 510776167 CHVBK 20180411083231.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s12975-013-0259-0 doi (NATIONALLICENCE)springer-10.1007/s12975-013-0259-0 Interaction Between vWF Levels and Aspirin Resistance in Ischemic Stroke Patients [Elektronische Daten] [Yıldız Arslan, Tahir Yoldaş, Yaşar Zorlu] The von Willebrand factor (vWF) levels increase in acute-phase ischemic stroke because of endothelial dysfunction and thrombus formation and may reduce acetylsalicylic acid (ASA) efficiency in hemostatic cascade. The aim of the study is to investigate the relationship between vWF levels and ASA resistance in ischemic stroke patients. Fifty acute ischemic stroke patients (mean age 66.3 ± 13years, 34 males) were given 300mg/day aspirin for at least 10days, and 25 healthy volunteers as a control group were compared using platelet function analyzer-100 test. All risk factors were investigated for a correlation to ASA resistance. ASA resistance was apparent in 32% of the study group and in 20% of the control group (p = 0.140). vWF levels were elevated in only ASA nonresponders and the ischemic stroke group that showed a statistically significant association with aspirin resistance (p ≤ 0.05). vWF levels increase in ASA nonresponders and ischemic stroke group in acute phase. High vWF levels may relate to ASA resistance and recurrent strokes. Springer Science+Business Media New York, 2013 ASA resistance nationallicence vWF levels nationallicence Ischemic stroke nationallicence Arslan Yıldız Neurology Clinic, İzmir Tepecik Education and Research Hospital, Yenişehir Mah, 35120, Konak, Izmir, Turkey aut Yoldaş Tahir Neurology Clinic, Ankara Dişkapi Education and Research Hospital, Ankara, Turkey aut Zorlu Yaşar Neurology Clinic, İzmir Tepecik Education and Research Hospital, Yenişehir Mah, 35120, Konak, Izmir, Turkey aut Translational Stroke Research Springer US; http://www.springer-ny.com 4/5(2013-10-01), 484-487 1868-4483 4:5<484 2013 4 12975 https://doi.org/10.1007/s12975-013-0259-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12975-013-0259-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Arslan Yıldız Neurology Clinic, İzmir Tepecik Education and Research Hospital, Yenişehir Mah, 35120, Konak, Izmir, Turkey aut NATIONALLICENCE 700 1- Yoldaş Tahir Neurology Clinic, Ankara Dişkapi Education and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Zorlu Yaşar Neurology Clinic, İzmir Tepecik Education and Research Hospital, Yenişehir Mah, 35120, Konak, Izmir, Turkey aut NATIONALLICENCE 773 0- Translational Stroke Research Springer US; http://www.springer-ny.com 4/5(2013-10-01), 484-487 1868-4483 4:5<484 2013 4 12975 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer