naa a22 4500 510776175 CHVBK 20180411083231.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s12975-013-0285-y doi (NATIONALLICENCE)springer-10.1007/s12975-013-0285-y Dynamic Contrast-Enhanced MRI Evaluation of Cerebral Cavernous Malformations [Elektronische Daten] [Blaine Hart, Saeid Taheri, Gary Rosenberg, Leslie Morrison] The aim of this study is to quantitatively evaluate the behavior of CNS cavernous malformations (CCMs) using a dynamic contrast-enhanced MRI (DCEMRI) technique sensitive for slow transfer rates of gadolinium. The prospective study was approved by the institutional review board and was HIPPA compliant. Written informed consent was obtained from 14 subjects with familial CCMs (4 men and 10 women, ages 22-76years, mean 48.1years). Following routine anatomic MRI of the brain, DCEMRI was performed for six slices, using T1 mapping with partial inversion recovery (TAPIR) to calculate T1 values, following administration of 0.025mmol/kg gadolinium DTPA. The transfer rate (Ki) was calculated using the Patlak model, and Ki within CCMs was compared to normal-appearing white matter as well as to 17 normal control subjects previously studied. All subjects had typical MRI appearance of CCMs. Thirty-nine CCMs were studied using DCEMRI. Ki was low or normal in 12 lesions and elevated from 1.4 to 12 times higher than background in the remaining 27 lesions. Ki ranged from 2.1E−6 to 9.63E−4min−1, mean 3.55E−4. Normal-appearing white matter in the CCM patients had a mean Ki of 1.57E−4, not statistically different from mean WM Ki of 1.47E−4 in controls. TAPIR-based DCEMRI technique permits quantifiable assessment of CCMs in vivo and reveals considerable differences not seen with conventional MRI. Potential applications include correlation with biologic behavior such as lesion growth or hemorrage, and measurement of drug effects. Springer Science+Business Media New York, 2013 MRI dynamic contrast enhanced nationallicence Brain/brain stem nationallicence Genetic defects nationallicence Hart Blaine Department of Radiology, University of New Mexico, MSC10 5530, 1, 87131-0001, Albuquerque, NM, USA aut Taheri Saeid Department of Radiology, Medical University of South Carolina, Bioengineering Bldg- 68 President St., MSC 323, RM 206, 29425, Charleston, SC, USA aut Rosenberg Gary Department of Neurology, University of New Mexico, MSC10 5620, 1, 87131-0001, Albuquerque, NM, USA aut Morrison Leslie Department of Neurology, University of New Mexico, MSC10 5620, 1, 87131-0001, Albuquerque, NM, USA aut Translational Stroke Research Springer US; http://www.springer-ny.com 4/5(2013-10-01), 500-506 1868-4483 4:5<500 2013 4 12975 https://doi.org/10.1007/s12975-013-0285-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12975-013-0285-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hart Blaine Department of Radiology, University of New Mexico, MSC10 5530, 1, 87131-0001, Albuquerque, NM, USA aut NATIONALLICENCE 700 1- Taheri Saeid Department of Radiology, Medical University of South Carolina, Bioengineering Bldg- 68 President St., MSC 323, RM 206, 29425, Charleston, SC, USA aut NATIONALLICENCE 700 1- Rosenberg Gary Department of Neurology, University of New Mexico, MSC10 5620, 1, 87131-0001, Albuquerque, NM, USA aut NATIONALLICENCE 700 1- Morrison Leslie Department of Neurology, University of New Mexico, MSC10 5620, 1, 87131-0001, Albuquerque, NM, USA aut NATIONALLICENCE 773 0- Translational Stroke Research Springer US; http://www.springer-ny.com 4/5(2013-10-01), 500-506 1868-4483 4:5<500 2013 4 12975 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer