naa a22 4500 510776280 CHVBK 20180411083231.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12975-012-0214-5 doi (NATIONALLICENCE)springer-10.1007/s12975-012-0214-5 Acute and Chronic Vascular Responses to Experimental Focal Arterial Stroke in the Neonate Rat [Elektronische Daten] [David Fernández-López, Joel Faustino, Nikita Derugin, Zinaida Vexler] The presence of active developmental angiogenesis and vascular outgrowth in the postnatal brain may differentially affect vascular responses to stroke in newborns and adults, but very little is known about the dynamics of vascular injury and regrowth after stroke during the neonatal period. In this study, we used a clinically relevant animal model of ischemic arterial stroke in neonate rats, a transient middle cerebral artery occlusion (MCAO) in postnatal day 7, to characterize the effects of injury on vascular density and angiogenesis from acute through the chronic phase. A marked vessel degeneration and suppressed endothelial cell proliferation occur in the ischemic regions early after neonatal stroke. In contrast to what has been described in adult animals, endothelial cell proliferation and vascular density are not increased in the peri-ischemic regions during the first week after MCAO in neonates. By 2weeks after injury, endothelial cell proliferation is increased in the cortical peri-ischemic region, but these changes are not accompanied by an increased vascular density. Suppressed angiogenesis in injured postnatal brain that we report may limit recovery after neonatal stroke. Thus, enhancement of angiogenesis after neonatal stroke may be a promising strategy for the long-term recovery of the affected newborns. Springer Science+Business Media, LLC, 2012 Neonatal stroke nationallicence Angiogenesis nationallicence Blood-brain barrier nationallicence Endothelial nationallicence Fernández-López David Neonatal Brain Disorders Center, Department of Neurology, University of California San Francisco, 675 Nelson Rising Lane, 94158-0663, San Francisco, CA, USA aut Faustino Joel Neonatal Brain Disorders Center, Department of Neurology, University of California San Francisco, 675 Nelson Rising Lane, 94158-0663, San Francisco, CA, USA aut Derugin Nikita Neonatal Brain Disorders Center, Department of Neurology, University of California San Francisco, 675 Nelson Rising Lane, 94158-0663, San Francisco, CA, USA aut Vexler Zinaida Neonatal Brain Disorders Center, Department of Neurology, University of California San Francisco, 675 Nelson Rising Lane, 94158-0663, San Francisco, CA, USA aut Translational Stroke Research Springer-Verlag 4/2(2013-04-01), 179-188 1868-4483 4:2<179 2013 4 12975 https://doi.org/10.1007/s12975-012-0214-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12975-012-0214-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fernández-López David Neonatal Brain Disorders Center, Department of Neurology, University of California San Francisco, 675 Nelson Rising Lane, 94158-0663, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Faustino Joel Neonatal Brain Disorders Center, Department of Neurology, University of California San Francisco, 675 Nelson Rising Lane, 94158-0663, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Derugin Nikita Neonatal Brain Disorders Center, Department of Neurology, University of California San Francisco, 675 Nelson Rising Lane, 94158-0663, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Vexler Zinaida Neonatal Brain Disorders Center, Department of Neurology, University of California San Francisco, 675 Nelson Rising Lane, 94158-0663, San Francisco, CA, USA aut NATIONALLICENCE 773 0- Translational Stroke Research Springer-Verlag 4/2(2013-04-01), 179-188 1868-4483 4:2<179 2013 4 12975 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer