naa a22 4500 510776310 CHVBK 20180411083231.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12975-013-0254-5 doi (NATIONALLICENCE)springer-10.1007/s12975-013-0254-5 The Potential for Cell-Based Therapy in Perinatal Brain Injuries [Elektronische Daten] [Andre Phillips, Michael Johnston, Ali Fatemi] Perinatal brain injuries are a leading cause of cerebral palsy worldwide. The potential of stem cell therapy to prevent or reduce these impairments has been widely discussed within the medical and scientific communities and an increasing amount of research is being conducted in this field. Animal studies support the idea that a number of stem cells types, including cord blood and mesenchymal stem cells have a neuroprotective effect in neonatal hypoxia-ischemia. Both these cell types are readily available in a clinical setting. The mechanisms of action appear to be diverse, including immunomodulation, activation of endogenous stem cells, release of growth factors, and anti-apoptotic effects. Here, we review the different types of stem cells and progenitor cells that are potential candidates for therapeutic strategies in perinatal brain injuries and summarize recent preclinical and clinical studies. Springer Science+Business Media New York, 2013 Stem cell nationallicence Cerebral palsy nationallicence Neonate nationallicence Brain injury nationallicence Hypoxia-ischemia nationallicence Phillips Andre The Hugo W. Moser Research Institute at Kennedy Krieger Institute, Johns Hopkins University, 707 N. Broadway 500I, 21205, Baltimore, MD, USA aut Johnston Michael The Hugo W. Moser Research Institute at Kennedy Krieger Institute, Johns Hopkins University, 707 N. Broadway 500I, 21205, Baltimore, MD, USA aut Fatemi Ali The Hugo W. Moser Research Institute at Kennedy Krieger Institute, Johns Hopkins University, 707 N. Broadway 500I, 21205, Baltimore, MD, USA aut Translational Stroke Research Springer-Verlag 4/2(2013-04-01), 137-148 1868-4483 4:2<137 2013 4 12975 https://doi.org/10.1007/s12975-013-0254-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12975-013-0254-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Phillips Andre The Hugo W. Moser Research Institute at Kennedy Krieger Institute, Johns Hopkins University, 707 N. Broadway 500I, 21205, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Johnston Michael The Hugo W. Moser Research Institute at Kennedy Krieger Institute, Johns Hopkins University, 707 N. Broadway 500I, 21205, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Fatemi Ali The Hugo W. Moser Research Institute at Kennedy Krieger Institute, Johns Hopkins University, 707 N. Broadway 500I, 21205, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Translational Stroke Research Springer-Verlag 4/2(2013-04-01), 137-148 1868-4483 4:2<137 2013 4 12975 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer