naa a22 4500 510778496 CHVBK 20180411083239.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s11948-012-9365-8 doi (NATIONALLICENCE)springer-10.1007/s11948-012-9365-8 Kelle Alexander Department of Politics, Languages and International Studies (PoLIS), University of Bath, Claverton Down, 1WN, BA2 7AY, Bath, UK aut Beyond Patchwork Precaution in the Dual-Use Governance of Synthetic Biology [Elektronische Daten] [Alexander Kelle] The emergence of synthetic biology holds the potential of a major breakthrough in the life sciences by transforming biology into a predictive science. The dual-use characteristics of similar breakthroughs during the twentieth century have led to the application of benignly intended research in e.g. virology, bacteriology and aerobiology in offensive biological weapons programmes. Against this background the article raises the question whether the precautionary governance of synthetic biology can aid in preventing this techno-science witnessing the same fate? In order to address this question, this paper proceeds in four steps: it firstly introduces the emerging techno-science of synthetic biology and presents some of its potential beneficial applications. It secondly analyses contributions to the bioethical discourse on synthetic biology as well as precautionary reasoning and its application to life science research in general and synthetic biology more specifically. The paper then identifies manifestations of a moderate precautionary principle in the emerging synthetic biology dual-use governance discourse. Using a dual-use governance matrix as heuristic device to analyse some of the proposed measures, it concludes that the identified measures can best be described as "patchwork precaution” and that a more systematic approach to construct a web of dual-use precaution for synthetic biology is needed in order to guard more effectively against the field's future misuse for harmful applications. Springer Science+Business Media B.V., 2012 Synthetic biology nationallicence Dual-use nationallicence Governance nationallicence Precautionary principle nationallicence Bioethics nationallicence Science and Engineering Ethics Springer Netherlands 19/3(2013-09-01), 1121-1139 1353-3452 19:3<1121 2013 19 11948 https://doi.org/10.1007/s11948-012-9365-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11948-012-9365-8 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Kelle Alexander Department of Politics, Languages and International Studies (PoLIS), University of Bath, Claverton Down, 1WN, BA2 7AY, Bath, UK aut NATIONALLICENCE 773 0- Science and Engineering Ethics Springer Netherlands 19/3(2013-09-01), 1121-1139 1353-3452 19:3<1121 2013 19 11948 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer