naa a22 4500 510779123 CHVBK 20180411083241.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s11892-012-0347-7 doi (NATIONALLICENCE)springer-10.1007/s11892-012-0347-7 Progression of β-Cell Dysfunction in Obese Youth [Elektronische Daten] [Cosimo Giannini, Sonia Caprio] The epidemic of childhood obesity has led to a remarkable increase in the prevalence of type 2 diabetes (T2D) among youth worldwide. The decreasing age at onset of T2D has alarming public health implications. In particular, the longer duration of the disease, as well as the faster onset and progression of T2D related complications, will present a considerable burden for young adults and a strain on public health. Therefore, it is important to understand the pathophysiology of early phases of disruption of glucose tolerance and identify those critical points in which diabetes may be prevented. β-Cell dysfunction has been shown to represent one of the key pathogenetic defects underlying the progression to diabetes in obese youth. In the present review, we describe longitudinal and cross-sectional studies of changes in insulin sensitivity and secretion across the spectrum of glucose tolerance in obese adolescents. Further, the role of ectopic fat accumulation is discussed in relation to its association with both β-cell dysfunction and insulin resistance. Springer Science+Business Media New York, 2012 β-Cell dysfunction nationallicence Obesity nationallicence Insulin resistance nationallicence Type 2 diabetes nationallicence Youth nationallicence Giannini Cosimo Department of Pediatrics, Yale University School of Medicine, 330 Cedar Street, P.O. Box 208064, 06520, New Haven, CT, USA aut Caprio Sonia Department of Pediatrics, Yale University School of Medicine, 330 Cedar Street, P.O. Box 208064, 06520, New Haven, CT, USA aut Current Diabetes Reports Current Science Inc. 13/1(2013-02-01), 89-95 1534-4827 13:1<89 2013 13 11892 https://doi.org/10.1007/s11892-012-0347-7 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-012-0347-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Giannini Cosimo Department of Pediatrics, Yale University School of Medicine, 330 Cedar Street, P.O. Box 208064, 06520, New Haven, CT, USA aut NATIONALLICENCE 700 1- Caprio Sonia Department of Pediatrics, Yale University School of Medicine, 330 Cedar Street, P.O. Box 208064, 06520, New Haven, CT, USA aut NATIONALLICENCE 773 0- Current Diabetes Reports Current Science Inc 13/1(2013-02-01), 89-95 1534-4827 13:1<89 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer