naa a22 4500 510779131 CHVBK 20180411083241.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s11892-012-0341-0 doi (NATIONALLICENCE)springer-10.1007/s11892-012-0341-0 Etiology of Insulin Resistance in Youth with Type 2 Diabetes [Elektronische Daten] [Melanie Cree-Green, Taylor Triolo, Kristen Nadeau] Type 2 diabetes (T2DM), historically an adult disease, is now increasingly prevalent in obese youth. Poor diet and increased sedentary behavior contribute to the increasing rates of obesity in youth, yet not all obese children develop T2DM. In general, T2DM is characterized by both insulin resistance (IR) and pancreatic beta-cell insufficiency. In children, IR is related to elevated body mass index (BMI) and pubertal hormones, along with abnormal fat partitioning, elevated free fatty acids, inflammation, and/or mitochondrial dysfunction. Hyperglycemia and T2DM develop when the pancreas cannot match the increased insulin demands resulting from IR. Unique to youth, IR varies with stage of pubertal development, and some children may have resolution of hyperglycemia post-puberty once the IR of puberty resolves. Further understanding of IR, the progression to T2DM in youth, and later outcomes as adults will help direct future therapies and interventions for youth at risk. Springer Science+Business Media New York, 2012 Type 2 diabetes nationallicence Insulin resistance nationallicence Pediatrics nationallicence Obesity nationallicence Cree-Green Melanie Division of Endocrinology, Department of Pediatrics, University of Colorado Denver and the Children's Hospital Colorado, 13123 E. Colfax Avenue, Box # 265, 80045, Aurora, CO, USA aut Triolo Taylor Division of Endocrinology, Department of Pediatrics, University of Colorado Denver and the Children's Hospital Colorado, 13123 E. Colfax Avenue, Box # 265, 80045, Aurora, CO, USA aut Nadeau Kristen Division of Endocrinology, Department of Pediatrics, University of Colorado Denver and the Children's Hospital Colorado, 13123 E. Colfax Avenue, Box # 265, 80045, Aurora, CO, USA aut Current Diabetes Reports Current Science Inc. 13/1(2013-02-01), 81-88 1534-4827 13:1<81 2013 13 11892 https://doi.org/10.1007/s11892-012-0341-0 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-012-0341-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cree-Green Melanie Division of Endocrinology, Department of Pediatrics, University of Colorado Denver and the Children's Hospital Colorado, 13123 E. Colfax Avenue, Box # 265, 80045, Aurora, CO, USA aut NATIONALLICENCE 700 1- Triolo Taylor Division of Endocrinology, Department of Pediatrics, University of Colorado Denver and the Children's Hospital Colorado, 13123 E. Colfax Avenue, Box # 265, 80045, Aurora, CO, USA aut NATIONALLICENCE 700 1- Nadeau Kristen Division of Endocrinology, Department of Pediatrics, University of Colorado Denver and the Children's Hospital Colorado, 13123 E. Colfax Avenue, Box # 265, 80045, Aurora, CO, USA aut NATIONALLICENCE 773 0- Current Diabetes Reports Current Science Inc 13/1(2013-02-01), 81-88 1534-4827 13:1<81 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer