naa a22 4500 51077914X CHVBK 20180411083241.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s11892-012-0336-x doi (NATIONALLICENCE)springer-10.1007/s11892-012-0336-x Impact of Hypoglycemia in Hospitalized Patients [Elektronische Daten] [Michelle Carey, Laura Boucai, Joel Zonszein] Hypoglycemia is a common problem in hospitalized patients, particularly the elderly, frail, and severely ill. Hypoglycemia has been implicated in the development of adverse clinical outcomes, including increased mortality. Fear of iatrogenic hypoglycemia remains an obstacle to adequate inpatient glycemic control. However, evidence from large clinical trials is mixed: several intensive care unit studies have shown either reduced or no change in mortality with intensive glycemic control, despite high rates of iatrogenic hypoglycemia, and only 1 large study showed higher mortality. In the general ward setting, the association of hypoglycemia with worse outcomes and mortality has been frequently reported, but after multivariate adjustment for comorbidities this association disappears. Spontaneous hypoglycemia, rather than iatrogenic hypoglycemia, is strongly associated with mortality suggesting that hypoglycemia behaves as a biomarker rather than a causative factor of adverse outcomes. Inpatient glycemic management should be patient-centered, follow the current guidelines, and aimed at preventing hypoglycemia. Springer Science+Business Media New York, 2012 Hypoglycemia nationallicence Mortality nationallicence Inpatient nationallicence Diabetes nationallicence Hospital nationallicence Carey Michelle Department of Medicine, Division of Endocrinology and Metabolism, Montefiore Medical Center, the University Hospital for Albert Einstein College of Medicine, 1825 Eastchester Road, 10461, Bronx, NY, USA aut Boucai Laura Department of Medicine, Division of Endocrinology and Metabolism, Montefiore Medical Center, the University Hospital for Albert Einstein College of Medicine, 1825 Eastchester Road, 10461, Bronx, NY, USA aut Zonszein Joel Department of Medicine, Division of Endocrinology and Metabolism, Clinical Diabetes Center, Montefiore Medical Center, the University Hospital for Albert Einstein College of Medicine, 1825 Eastchester Road, 10461, Bronx, NY, USA aut Current Diabetes Reports Current Science Inc. 13/1(2013-02-01), 107-113 1534-4827 13:1<107 2013 13 11892 https://doi.org/10.1007/s11892-012-0336-x text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-012-0336-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Carey Michelle Department of Medicine, Division of Endocrinology and Metabolism, Montefiore Medical Center, the University Hospital for Albert Einstein College of Medicine, 1825 Eastchester Road, 10461, Bronx, NY, USA aut NATIONALLICENCE 700 1- Boucai Laura Department of Medicine, Division of Endocrinology and Metabolism, Montefiore Medical Center, the University Hospital for Albert Einstein College of Medicine, 1825 Eastchester Road, 10461, Bronx, NY, USA aut NATIONALLICENCE 700 1- Zonszein Joel Department of Medicine, Division of Endocrinology and Metabolism, Clinical Diabetes Center, Montefiore Medical Center, the University Hospital for Albert Einstein College of Medicine, 1825 Eastchester Road, 10461, Bronx, NY, USA aut NATIONALLICENCE 773 0- Current Diabetes Reports Current Science Inc 13/1(2013-02-01), 107-113 1534-4827 13:1<107 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer