naa a22 4500 510779158 CHVBK 20180411083241.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s11892-012-0344-x doi (NATIONALLICENCE)springer-10.1007/s11892-012-0344-x Developmental Origins of Obesity: Programmed Adipogenesis [Elektronische Daten] [Mina Desai, Marie Beall, Michael Ross] The metabolic syndrome epidemic, including a marked increase in the prevalence of obesity and gestational diabetes mellitus (GDM) among pregnant women, represents a significant public health problem. There is increasing recognition that the risk of adult obesity is clearly influenced by prenatal and infant environmental exposures, particularly nutrition. This tenet is the fundamental basis of developmental programming. Low birth weight, together with infant catch-up growth, is associated with a significant risk of adult obesity. Exposure to maternal obesity, with or without GDM, or having a high birth weight also represents an increased risk for childhood and adult obesity. Animal models have replicated human epidemiologic findings and elucidated potential programming mechanisms that include altered organ development, cellular signaling responses, and epigenetic modifications. Prenatal care has made great strides in optimizing maternal, fetal, and neonatal health, and now has the opportunity to begin interventions which prevent or reduce childhood/adult obesity. Guidelines that integrate optimal pregnancy nutrition and weight gain, management of GDM, and newborn feeding strategies with long-term consequences on adult obesity, remain to be elucidated. Springer Science+Business Media New York, 2012 Maternal obesity nationallicence Gestation diabetes mellitus nationallicence Birth weight nationallicence Catch-up growth nationallicence Developmental origins of obesity nationallicence Programmed adipogenesis nationallicence Desai Mina Perinatal Research Laboratories, Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California, Los Angeles, Harbor-UCLA Medical Center, 90502, Los Angeles, CA, USA aut Beall Marie Los Angeles Perinatal Association, Los Angeles, CA, USA aut Ross Michael Perinatal Research Laboratories, Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California, Los Angeles, Harbor-UCLA Medical Center, 90502, Los Angeles, CA, USA aut Current Diabetes Reports Current Science Inc. 13/1(2013-02-01), 27-33 1534-4827 13:1<27 2013 13 11892 https://doi.org/10.1007/s11892-012-0344-x text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-012-0344-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Desai Mina Perinatal Research Laboratories, Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California, Los Angeles, Harbor-UCLA Medical Center, 90502, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Beall Marie Los Angeles Perinatal Association, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Ross Michael Perinatal Research Laboratories, Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California, Los Angeles, Harbor-UCLA Medical Center, 90502, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Current Diabetes Reports Current Science Inc 13/1(2013-02-01), 27-33 1534-4827 13:1<27 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer