naa a22 4500 510779298 CHVBK 20180411083241.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s11892-012-0343-y doi (NATIONALLICENCE)springer-10.1007/s11892-012-0343-y Kapadia Chirag Division of Endocrinology and Diabetes, Phoenix Children's Hospital, 1919 E Thomas Road, 85016, Phoenix, AZ, USA aut Are the ADA Hemoglobin A1c Criteria Relevant for the Diagnosis of Type 2 Diabetes in Youth? [Elektronische Daten] [Chirag Kapadia] Diagnostic criteria for diabetes in children have not been established with nearly the rigor as that employed in adults. Recently revised American Diabetes Association (ADA) criteria allowed utilization of hemoglobin A1c (HbA1c) ≥6.5% for diagnosis of diabetes. A recent series of pediatric studies appear to show that HbA1c has lower sensitivity than Fasting plasma glucose (FPG) or oral glucose tolerance test (OGTT). However, FPG and OGTT have themselves never been validated in children. Studies to validate diagnostic thresholds in children appear unlikely to take place. Thus, accepting the major ADA diagnostic criteria appears to be the best course of action for the pediatric community. One area in which correlation studies between HbA1c and FPG or OGTT might shed light is in the definition of criteria for intervention in ‘pre-diabetes,' as the Diabetes Prevention Program Trial did not use HbA1c. However, such treatment, and the exact diagnostic thresholds at which it should be initiated in children, remains unproven. Springer Science+Business Media New York, 2012 Hemoglobin A1c nationallicence HbA1c nationallicence Diagnosis of diabetes nationallicence Obesity nationallicence Children nationallicence American Diabetes Association nationallicence OGTT nationallicence Fasting plasma glucose nationallicence Retinopathy nationallicence Type 2 diabetes nationallicence Youth nationallicence Current Diabetes Reports Current Science Inc. 13/1(2013-02-01), 51-55 1534-4827 13:1<51 2013 13 11892 https://doi.org/10.1007/s11892-012-0343-y text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-012-0343-y text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Kapadia Chirag Division of Endocrinology and Diabetes, Phoenix Children's Hospital, 1919 E Thomas Road, 85016, Phoenix, AZ, USA aut NATIONALLICENCE 773 0- Current Diabetes Reports Current Science Inc 13/1(2013-02-01), 51-55 1534-4827 13:1<51 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer