naa a22 4500 510779352 CHVBK 20180411083241.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s11892-013-0432-6 doi (NATIONALLICENCE)springer-10.1007/s11892-013-0432-6 Environmental Chemicals and Type 2 Diabetes: An Updated Systematic Review of the Epidemiologic Evidence [Elektronische Daten] [Chin-Chi Kuo, Katherine Moon, Kristina Thayer, Ana Navas-Acien] The burden of diabetes is increasing globally. Identifying novel preventable risk factors is an urgent need. In 2011, the U.S. National Toxicological Program (NTP) conducted a workshop to evaluate the epidemiologic and experimental evidence on the relationship of environmental chemicals with obesity, diabetes, and metabolic syndrome. Although the evidence was insufficient to establish causality, the NTP workshop review identified an overall positive association between some environmental chemicals and diabetes. In the present systematic review, our objective was to summarize the epidemiological research published since the NTP workshop. We identified a total of 29 articles (7 on arsenic, 3 on cadmium, 2 on mercury, 11 on persistent organic pollutants, 3 on phthalates, and 4 on bisphenol A), including 7 prospective studies. Considering consistency, temporality, strength, dose-response relationship, and biological plausibility (confounding), we concluded that the evidence is suggestive but not sufficient for a relationship between arsenic and persistent organic pollutants and is insufficient for mercury, phthalates, and bisphenol A. For cadmium, the epidemiologic evidence does not seem to suggest an association with diabetes. Important research questions include the need for additional prospective studies and the evaluation of the dose-response relationship, the role of joint exposures, and effect modification with other comorbidities and genetic variants. Springer Science+Business Media New York, 2013 Systematic review nationallicence Environmental chemicals nationallicence Diabetes nationallicence Arsenic nationallicence Cadmium nationallicence Mercury nationallicence Persistent organic pollutants nationallicence Bisphenol A nationallicence Phthalates nationallicence Type 2 diabetes nationallicence Epidemiology nationallicence Kuo Chin-Chi Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA aut Moon Katherine Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA aut Thayer Kristina Office of Health Assessment and Translation, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA aut Navas-Acien Ana Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA aut Current Diabetes Reports Springer US; http://www.springer-ny.com 13/6(2013-12-01), 831-849 1534-4827 13:6<831 2013 13 11892 https://doi.org/10.1007/s11892-013-0432-6 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11892-013-0432-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kuo Chin-Chi Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Moon Katherine Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Thayer Kristina Office of Health Assessment and Translation, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA aut NATIONALLICENCE 700 1- Navas-Acien Ana Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Current Diabetes Reports Springer US; http://www.springer-ny.com 13/6(2013-12-01), 831-849 1534-4827 13:6<831 2013 13 11892 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer